The Mosher laboratory is seeking two new team members to join us in revealing the genomic and developmental consequences of small RNA directed DNA methylation (RdDM) during seed development. We use multiple plant systems in the Brassicacaeae family, including Arabidopsis, Brassica, and Capsella, and we utilize a variety of molecular and sequence-based approaches to analyze small RNAs and DNA methylation. Our goal is to understand how small RNAs establish epigenomic patterns during sexual reproduction, including interactions between parental and zygotic cells. As a diverse and international group of scientists, we value research integrity, personal and professional development, and a healthy work-life balance. To foster in our community, we encourage applicants from diverse perspectives and backgrounds to apply.

We are seeking two postdoctoral researchers to lead projects investigating how the evolution of self-fertilization impacts genome and epigenome variation. We will analyze Capsella species representing multiple independent transitions to selfing to identify common (epi)genomic features associated with this mating system transition. This work is part of a collaboration with Dr. Andrea Sweigart’s lab at the University of Georgia who are investigating how selfing influences (epi)genomes in Mimulus species, and the two laboratories will cooperate to enhance our findings.

Outstanding UA benefits include health, dental, vision, and life insurance; paid vacation, sick leave, and holidays; UA/ASU/NAU tuition reduction for the employee and qualified family members; access to UA recreation and cultural activities; and more!

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The first project will determine how the transition to self-fertilization impacts transposons, including host defenses against these elements and collateral impacts on nearby genes. We are generating new, nearly gapless assemblies of multiple Capsella species to aid in this analysis and similar work in the Sweigart lab will allow a robust comparison of transposon biology in inbreeding and outbreeding species.

The second project will investigate the production and function of siren siRNAs during seed development in inbreeding and outbreeding species. Previous work in the Mosher lab has revealed that these highly abundant, maternal-specific siRNAs are required for seed development in outbreeding species (Grover JW, et al Plant J 2018; Grover JW, et al PNAS 2020; Burgess D, et al Plant Cell 2022; Dew-Budd KJ, et al BioRxiv).

Both projects require proficiency in genomics and bioinformatic analysis of high throughput sequence data. Successful applicants will also have a PhD in the life sciences and a record of research productivity. Experience in plant systems is not required, but good communication skills, organization, and record-keeping are essential. The ideal candidate will be able to work independently to move a project forward while operating in a collaborative research environment. It is also expected that these projects will be a launchpad for additional research questions and Prof. Mosher will support the development of a future independent research program.

• Design and conduct research to answer important questions relevant to RNA-directed DNA methylation and 24-nt siRNA production during seed development, including appropriate controls, statistical analysis, and record keeping.
• Oversee or perform sowing, cultivation, and harvest of research material, including mutants and transgenic plants. Most routine horticultural needs (e.g., watering) are performed by lab assistants.
• Maintain daily written records of research activities.
• Summarizing research findings in multiple graphical formats using appropriate software (e.g., ggplot, Adobe Photoshop).
• Prepare written reports and draft manuscripts for assigned research projects
• Stay abreast of current literature related to the research program and integrate new findings or approaches into research projects.
• Organize, supervise, and mentor undergraduate students to ensure research is conducted efficiently, safely, and appropriately.
• Meet regularly with supervisor to discuss research progress and determine next steps.
• Present research progress at weekly lab and departmental meetings, and contribute to the discussion when others present.
• Understanding of genomes and genetics, including control of gene expression.
• Proficiency with analysis of high throughput sequencing libraries (RNAseq, sRNAseq, ChIPseq and/or whole genome bisulfite seq).
• The ability to distill and clearly communicate complex scientific concepts, especially research findings, both orally and in written form.
• The capacity to work independently, while maintaining good communication with supervisor and other members of the laboratory.
• Understand how to find, read, interpret, and integrate scientific literature.
• Contribute to a safe and positive work environment for everyone.

• PhD with a dissertation related to genomics, plant biology, epigenetics upon hire.