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Work type:Faculty/Academic Staff
Major Administrative Unit / College: College Of Human Medicine
Department: Translational Neuroscience 40000320
Sub Area: FAS- Fac./Acad Staff
Salary: Salary Commensurate with Experience
Location:Grand Rapids
Categories:Research/Scientific, Fixed Term Academic Staff, Full Time (90-100%), Non-Union

A postdoctoral Research Associate is being sought to work in the Parkinson’s disease (PD) research laboratory of Dr. Caryl Sortwell, Professor in the Department of Translational Neuroscience. This postdoctoral researcher will participate in research to investigate the impact of rho kinase inhibition on the pathology and transcriptome in a rat model of PD. The ability of pharmacological inhibition of rho kinase to prevent alpha-synuclein aggregation and/or nigrostriatal degeneration as well as the impact on the dopaminergic neuron and microglial transcriptome will be investigated. A multitude of experimental approaches that include protein biochemistry, stereotaxic surgery, immunohistochemistry, laser capture microdissection, RNA-Seq analysis and in situ hybridization will be used with the end goal of determining the neuroprotective potential of rho kinase inhibition. Training will be provided in techniques as needed. The fellow will also be trained and participate in collaborative experimental design and execution, analysis of data and scholarly communication of results for publication in peer-reviewed journals and scientific conferences. This position is appointed on an annual basis for and will require the applicant to work across multiple laboratories. This position is located at the MSU Grand Rapids Research Center, 400 Monroe Ave NW, Grand Rapids, MI.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.

Doctorate

• This position requires a doctoral degree in biological sciences, pharmacology or cell biology with an emphasis on molecular neuroscience preferable;
• 0-2 years experience working in a basic science laboratory postdoctorally;
• should have essential basic skills in standard molecular biology, biochemistry, rodent handling and stereotactic surgery.
• Skills needed are experience with data generation and handling, data interpretation, writing up laboratory procedures and results, the ability to supervise students, and the use of standard computer software.
• Excellent written and spoken communication skills are required.

• Knowledge and/or experience with gene expression, recombinant protein production, rodent handling and in situ hybridization.
• The successful applicant should be proficient with basic statistical analyses as would normally be expected for a doctoral level biomedical researcher.

• CV or NIH-style biosketch
• Cover Letter
• Names of 3 references

The university is requiring all MSU students, faculty and staff to be vaccinated against COVID-19 with limited exceptions. Learn more at:

08/26/2022

Work with animals or unfixed animal tissue

The nationally ranked Department of Translational Neuroscience within CHM focuses on neurodegenerative diseases of aging including Parkinson’s disease, Alzheimer’s disease, allied dementias and traumatic brain injury. Translational Neuroscience is headquartered in the Grand Rapids Innovation Park within the state-of-the-art Grand Rapids Research Center (GRRC). The over $200 million expansion of CHM in Grand Rapids is a coordinated effort among local partner medical systems (Spectrum Health, Mercy Health Saint Mary’s) and research-intensive institutions (CHM, Van Andel Research Institute) to bring basic researchers and clinicians together to create unified translational science initiatives. With these resources, CHM and its partner institutions in Grand Rapids have laid the foundation to create a regional geographic nexus unparalleled in its commitment to neuroscience research excellence.

Michigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

Advertised:Aug 19, 2022 Eastern Daylight Time
Applications close:Aug 19, 2024 Eastern Daylight Time