This Position is Fully Grant Funded
School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nationâ€™s top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
A HIV-1 Envelope (Env) vaccine that elicits broadly neutralizing antibodies (bnAbs) has remained elusive, in part due to our limited understanding of the mechanisms of bnAb induction during natural infection. Recently developed simian-human chimeric immunodeficiency viruses (SHIVs) bearing Envs from HIV-1 transmitted-founder (TF) viruses associated with bnAb induction in HIV-1 infected adult individuals now provide an experimental model to establish the mechanisms of bnAb development. HIV-1 Env bnAbs develop in ~50% of chronically-infected adults in over 3-5 years of infection, but HIV-1-infected infants and children more frequently develop bnAbs and do so faster than adults. Understanding the cellular and molecular mechanisms of infant and adult bnAb development will facilitate design of vaccine strategies to elicit bnAbs.
Dr. Williams is investigating HIV-1 Env-reactive antibody immunity, including bnAb induction in mom-baby pairs of pathogenic SHIV-infected rhesus macaques; the results of which can inform HIV-1 vaccine design in humans. He is seeking a bright and talented PhD or MD/PhD recent graduate with preferably Immunology training for a postdoctoral position to study neonatal and adult immunity to novel SHIVs. This proactive candidate will be self-motivated and committed to their research, and willing to undertake multiple molecular biology approaches to address an area of HIV research that is understudied. Here at the Duke Human Vaccine Institute, we value collaborations, and pride ourselves in providing an excellent environment for academic and professional growth.
Education, Skills, & Experience Requirements
- PhD in biological science or related field
- MD/PhD with molecular biology research experience
- Must be able to manage multiple and rapidly changing priorities and have ability to quickly learn new skills
- Must be detail-oriented, well organized with strong communication skills and ability to work in an interactive team environment.
How to Apply:
Interested applicants should also email CV, brief statement of research interests and names & contact information for three references to Dr. Wilton Williams at firstname.lastname@example.org
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