BSD PAT - Schreiber Lab
About the Department
The laboratory focuses on the separate as well as combined therapeutic effects of CD4 and CD8 T cells recognizing mutation-encoded cancer-specific antigens on murine or human cancers. The Schreiber laboratory has contributed to a number of important discoveries in the field of cancer immunotherapy, including the identification of the genetic nature of unique tumor-specific antigens and that non-synonymous single nucleotide substitutions causing single amino acid replacements are the basis of the unique individually specific immunogenicity of cancers. The Schreiber lab uses mouse models to study T cell-mediated immunotherapy of progressively growing tumors and how tumor-stroma modifies the therapeutic outcome. The lab uses a combination of sophisticated in vivo and in vitro methodologies (including imaging) ranging from the molecular, cell culture, tissue to the whole-body level.
The job facilitates and promotes a research project or contributes to the scientific direction of a research resource. Receives a moderate level of guidance and direction. Research Professional will study/develop adoptive T cell therapies in mouse models and humans using syngeneic/autologous
mutation specific TCRs engineered to be expressed in peripheral blood T cells. The incumbent will work in close collaboration with our team of leading scientists at the University of Chicago and abroad.
Directs a comprehensive program leading to the development of autologous T cell-receptor (TCR) therapy targeting cancer-specific mutations in mice as well as in patients.
Not only conducts experiments and assays but also trains and guides members of the laboratory. Collaborates with a bioinformatics group to identify the trunk mutations that are well expressed.
Selects appropriate tumor-specific targets for therapy.
Renewal and updating of existent and/or completion of new animal research, biosafety and radiation as well as clinical research protocols.
Making, ordering, training and receiving of culture media and reagents.
Preparation of sterile supplies including glassware. Training and supervision of others to take over these tasks.
Writes up (detailed design) and executes experiments discussed with the principle investigator (PI). Training and supervision of others to take over these tasks.
Maintaining a liquid nitrogen cell bank. Training and supervision of others to take over these tasks.
Guides, motivates and encourages incoming graduate and undergraduate students, postdoctoral fellows, residents and visiting researchers, and to interact productively with other faculty inside and outside the University.
Serves as a resource for collecting data and performing analysis. Contributes to facilitating and promoting a research project by providing scientific or intellectual information.
Reviews laboratory protocols and training on new techniques. Manage complex data sets for research.
Leads the contributions to scientific writing and publications, including protocols and grants.
Trains new laboratory personnel.
Performs other related work as needed.
Minimum requirements include a PhD in related field.
Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.
Experience in 10xGenomics preparation and downstream analyses, NSG analyses, TIL, B and T cell cultures and separation techniques, vector construction and methods for TCR transfer by viral transduction, electroporation and CRISPR-CAS.
Excellent knowledge of cellular and molecular immunology, and genetics with strong wet lab skills in these areas.
Demonstrated independence in experimental design and execution.
An excellent knowledge of spoken and written English.
Excellent quantitative skills.
Understand the ongoing research projects and related literature, participation in journal clubs and research seminars and training.
Ability to conduct research independently.
Ability to work effectively in a collaborative team setting.
Proficiency in computers, particularly data base search and data entry. Maintain procedure and reagent books.
Ability to perform the duties of other team members in the laboratory for backup, demonstration, and training.
Cover Letter (preferred)
When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.
Scheduled Weekly Hours
Requires Compliance with University Covid-19 Vaccination Requirement
Drug Test Required
Health Screen Required
Motor Vehicle Record Inquiry Required
Employees must comply with the University’s COVID-19 vaccination requirements. More information about the requirements can be found on the University of Chicago Vaccination GoForward .
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