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Postdoctoral Research Associate - Gastroenterology
University of Washington in Medical Lake, Washington
 
 
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Date Posted 03/27/2022
Category
Admin-Laboratory and Research
Employment Type FullTime
Application Deadline Open until filled
 
 
 
 
 

Job Description

Position Summary

This position is in the Department of Internal Medicine, Division of Gastroenterology. This position is for the Medical School Campus. The Ciorba Lab (Gastroenterology) is seeking a motivated post-doctoral fellow to join our mission driven research team to lead studies on host-microbial interactions in intestinal health and disease.  It is anticipated that successful candidate will join our team’s efforts to define the mechanisms of intestinal COVID-19 and its interactions with IBD using novel mouse models, cell culture, and human organoids. These NIH funded studies will be in collaboration with our expert virology team. Further opportunities are available to develop an independent career development project.

We are a diverse, team-oriented, basic-translational lab researching mechanisms and pathways of intestinal disease https://ciorbalab.wustl.edu . Ultimately, our goal is to leverage this understanding to identify novel therapeutic approaches that will address the unmet needs of patients affected by inflammatory bowel disease (IBD: Crohn's disease, ulcerative colitis), as well as colon cancer. A major investigational focus is on the intestinal epithelium and intestinal stem cell function during cycles of injury and repair. To achieve this we use modern molecular and microbiology tools, animal models (mice), human tissues, and intestinal organoids (mouse and human derived). We were among the first labs in the world to demonstrate that SARS-CoV-2 could infect human intestinal epithelial cells.

The postdoctoral researcher will have the opportunity to work with welcoming collaborators across the GI division, the School of Medicine and across the US to develop this project and their own independent project. The GI division has an NIDDK funded Digestive Diseases Research Center (https://ddrcc.wustl.edu/ ) with numerous resources for investigation and funding. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups.

Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs/ .

Primary Duties and Responsibilities

Trains under the supervision of a faculty mentor, including (but not limited to):

  • Manages their own project, which should lead to a first author publication.
  • Develops robust expertise in intestinal inflammation and host-microbial interactions that drive disease.
  • Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
  • Presents scientific work both inside and outside the University with excellent oral communication skills.
  • Assists with grant preparation and reporting.
  • Designs research experiments, evaluates findings, and reports results in high quality research papers.
  • Maintains conscientious discharge of their research responsibilities and conformity with ethical standards in research.
  • Maintains compliance with good laboratory practice including the maintenance of adequate research records.
  • Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
  • Maintains collegial conduct towards co-trainees, staff members and members of the research group.
  • Adheres to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.
  • Performs other duties as assigned.

Required Qualifications

Ph.D., M.D. or equivalent terminal or doctoral degree.

Preferred Qualifications

  • Experience with techniques in molecular and microbiology, as well as basic human cell culture.
  • Knowledge of basic mucosal immunology/pathobiology.
  • Experience in, or comfortable with, the concept of using mouse models of GI disease.
  • Background in gastrointestinal research and/or a closely related field in epithelial/mucosal disease.
  • Strong oral and written communication skills.
  • Ability to perform the work described and wear protective equipment when necessary.
  • Outstanding documentation and organized record-keeping skills.
  • Experience with and motivated to improve in experimental troubleshooting, as well as critical, analytical, and creative thinking skills.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

Please send a C.V., cover letter, and list of three references with contact information to Dr. Matthew Ciorba at ibd@wustl.edu . Use subject line "Post Doc".


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

Job Description

Position Summary

This position is in the Department of Internal Medicine, Division of Gastroenterology. This position is for the Medical School Campus. The Ciorba Lab (Gastroenterology) is seeking a motivated post-doctoral fellow to join our mission driven research team to lead studies on host-microbial interactions in intestinal health and disease.  It is anticipated that successful candidate will join our team’s efforts to define the mechanisms of intestinal COVID-19 and its interactions with IBD using novel mouse models, cell culture, and human organoids. These NIH funded studies will be in collaboration with our expert virology team. Further opportunities are available to develop an independent career development project.

We are a diverse, team-oriented, basic-translational lab researching mechanisms and pathways of intestinal disease https://ciorbalab.wustl.edu . Ultimately, our goal is to leverage this understanding to identify novel therapeutic approaches that will address the unmet needs of patients affected by inflammatory bowel disease (IBD: Crohn's disease, ulcerative colitis), as well as colon cancer. A major investigational focus is on the intestinal epithelium and intestinal stem cell function during cycles of injury and repair. To achieve this we use modern molecular and microbiology tools, animal models (mice), human tissues, and intestinal organoids (mouse and human derived). We were among the first labs in the world to demonstrate that SARS-CoV-2 could infect human intestinal epithelial cells.

The postdoctoral researcher will have the opportunity to work with welcoming collaborators across the GI division, the School of Medicine and across the US to develop this project and their own independent project. The GI division has an NIDDK funded Digestive Diseases Research Center (https://ddrcc.wustl.edu/ ) with numerous resources for investigation and funding. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups.

Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs/ .

Primary Duties and Responsibilities

Trains under the supervision of a faculty mentor, including (but not limited to):

  • Manages their own project, which should lead to a first author publication.
  • Develops robust expertise in intestinal inflammation and host-microbial interactions that drive disease.
  • Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
  • Presents scientific work both inside and outside the University with excellent oral communication skills.
  • Assists with grant preparation and reporting.
  • Designs research experiments, evaluates findings, and reports results in high quality research papers.
  • Maintains conscientious discharge of their research responsibilities and conformity with ethical standards in research.
  • Maintains compliance with good laboratory practice including the maintenance of adequate research records.
  • Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
  • Maintains collegial conduct towards co-trainees, staff members and members of the research group.
  • Adheres to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.
  • Performs other duties as assigned.

Required Qualifications

Ph.D., M.D. or equivalent terminal or doctoral degree.

Preferred Qualifications

  • Experience with techniques in molecular and microbiology, as well as basic human cell culture.
  • Knowledge of basic mucosal immunology/pathobiology.
  • Experience in, or comfortable with, the concept of using mouse models of GI disease.
  • Background in gastrointestinal research and/or a closely related field in epithelial/mucosal disease.
  • Strong oral and written communication skills.
  • Ability to perform the work described and wear protective equipment when necessary.
  • Outstanding documentation and organized record-keeping skills.
  • Experience with and motivated to improve in experimental troubleshooting, as well as critical, analytical, and creative thinking skills.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

Please send a C.V., cover letter, and list of three references with contact information to Dr. Matthew Ciorba at ibd@wustl.edu . Use subject line "Post Doc".


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

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