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Research Scientist - Mass Spectrometry (Biomedical Sciences)
Creighton University in Omaha, Nebraska
Date Posted 03/13/2022
Admin-Laboratory and Research
Employment Type
Application Deadline Open until filled

The Mass Spectrometry Research Scientist will be joining the Translational Hearing Center at Creighton University. The Translational Hearing Center, an NIH/NIGMS-funded Center of Biomedical Research Excellence (CoBRE) committed to developing a cadre of translational auditory/vestibular research scientists developing biomedical and ototherapeutic solutions that preserve or restore hearing and vestibular function. We currently support 3 Research Projects Leaders (each at $200k per year for up to three years) and 4 Pilot Project Awardees (each at $50k for 1 year). The Centre has 2 specialized Research Cores, the Auditory & Vestibular Technology (AVT) Core, and the Drug Discovery & Delivery Core (DDDC), to assist researchers in meeting their research goals. The Mass Spectrometry Research Scientist is a member of the Auditory & Vestibular Technology Core.
The Mass Spectrometry Research Scientist is responsible for employing mass spectrometry to design and execute experiments and collect and interpret data in support of the goals and specific aims of the Translational Hearing Center. Specifically, the Mass Spectrometry Research Scientist is responsible for calibrating the Thermo QExactive instrument at least once a week, accepting samples for analysis, sample preparation, tuning the instrument for improved separation and detection of analytes and ions, developing internal standards where appropriate, validating standard curves for quantitative studies including determining limit-of-detection (LOD) and limit-of-quantitation (LOQ) levels, batch processing of raw files to collect data, interpretation of final results and writing final reports.  In addition, the Mass Spectrometry Research Scientist performs daily, weekly and monthly maintenance of the Thermo QExactive mass spectrometer, Vanquish UHPLC and nLC1200 chromatography instruments. Position requires ability to troubleshoot issues with instrumentation or results and correct issues as they arise. The Mass Spectrometry Research Scientist must have a broad background in mass spectrometry, strong analytical skills, strong oral and written communication skills, and a proven track record of mass spectrometry-based experiments.
Reporting to the Director of the Mass Spectrometry sub-core, the Mass Spectrometry Research Scientist will be managing the daily operations of the AVT Mass Spectrometry sub-core Lab.  They will collaborate with other lab managers in developing training, webinars etc to train students, faculty and staff on instruments and experiments within the AVT Mass Spectrometry sub-core. The Mass Spectrometry Research Scientist will oversee quality control to ensure high quality, timely and ethical lab activities. 
 Job Specific Duties and Responsibilities:
•    Work with RPLs and PIs to develop mass spectrometric methods in support of the goals of the THC. Process and review all data per internal procedures for identifying positive results
•    Maintain the Thermo QExactive LC-MS/MS instrument according to internal maintenance schedules. Troubleshoot any issues that arise during normal sample analysis.
•    Participate in any method validation studies that need to be performed, and coordinate validation efforts with prep team
•    Participate in the proficiency testing program
•    Communicate with management when any problems arise than cannot be resolved
•    LC-MS/MS analysis of small molecules.
•    LC-MS/MS analysis of lipid membrane components (lipidomics)
•    General Knowledge of statistics/biostatistics 
•    Working knowledge of Thermo mass spectrometers.
•    Familiarization with XCalibur operating software
•    Experience with mass-imaging.
This position is partially grant funded.
This position will work Monday to Friday; normal business hours; depending upon research needs, the position may require evening, weekend, and holiday work. 

Master's Degree in related field of Science; Doctoral degree or equivalent preferred.
Seven (7) years of research experience in related field and/or 3 years of experience as a postdoctoral researcher.

Knowledge, Skills, Abilities:
Experience with LC-MS/MS analysis of small molecules;
Experience with LC-MS/MS analysis of lipid membrane components (Lipidomics);
General Knowledge of statistics/biostatistics;
Working knowledge of Thermo mass spectrometers;
Familiarization with Xcalibur operating software;
Experience with mass imagining; 
Proficiency in Microsoft Office Suite to include Word, Excel; PowerPoint and Outlook;
Strong interpersonal skills (verbal and written);
Ability to develop rapport quickly and effectively with a diversity of populations;
Mission/Service and Results oriented;
Ability to work at times non-traditional business hours when needed (i.e. weekends, evening, and/or holiday)

Physical Requirements:
Seeing: 75-100%
Hearing: 50-74%
Standing/Climbing/Mobility: 0-24%
Lifting/Pulling/Pushing: 0-24% (up to 15 lbs.)
Fingering/Grasping/Feeling: 75-100%
Travel: No
Exposure to Blood Borne pathogens: Yes
Working with Animals:  No 
AAP/EEO Statement:
Creighton University is committed to providing a safe and non-discriminatory educational and employment environment. The University admits qualified students, hires qualified employees and accepts patients for treatment without regard to race, color, religion, sex, marital status, national origin, age, disability, citizenship, sexual orientation, gender identity, gender expression, veteran status, or other status protected by law. Its education and employment policies, scholarship and loan programs, and other programs and activities, are administered without unlawful discrimination.
Disclosure Statement:
This description describes the general nature of work to be performed and does not include an exhaustive list of all duties, skills, or abilities required. Regular, reliable attendance is an essential function and all employees are required to follow any other job-related instructions and to perform any other job-related duties as requested by their supervisor. Employees may also be required to work in excess of normal working hours as workloads and seasonal activities necessitate. A complete description is available in the Human Resource office located at 3006 Webster Street Omaha, NE. Creighton University reserves the right to modify duties, responsibilities and activities at any time with or without notice.

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