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Senior Scientist - Cardiology
University of Washington in Medical Lake, Washington
 
 
Apply
 
Date Posted 03/08/2022
Category
Admin-Other Administrative Positions
Employment Type FullTime
Application Deadline Open until filled
 
 
 
 
 

Scheduled Hours
40


Position Summary
The interest of this academic laboratory (PI:  Babak Razani) is understanding the mechanisms of atherosclerosis, diabetes, obesity, and fatty liver disease with special emphasis on the roles of macrophages.  We and others have shown that perturbations in cellular processes involving mTOR and nutrient sensing, autophagy and lysosomes, and inflammatory signaling, including inflammasomes play a critical role in macrophage dysfunction and subsequent cardiometabolic disease. Some of our relevant primary papers include (Sergin, et al Science Signaling 2016 and Sergin, et al Nature Communications 2017; Evans, et al Science Signaling 2019; Zhang, et al Nature Metabolism 2020; Jeong, et al Autophagy 2021).  The primary focus of the lab will be to understand the mechanisms by which these cellular processes affect metabolism, determine if their manipulation ameliorates metabolic disease, and translate our findings to develop novel therapeutics in human coronary artery disease, obesity, and insulin resistance. These questions are being studied using a combination of molecular and cell biology approaches in mouse primary cells/cell-lines, mouse models, human monocytes/monocyte-derived macrophages, induced pluripotent stem cell (iPSC)-derived macrophages, and circulating monocytes and tissue macrophages from humans enrolled in clinical studies. Additionally, there is a recent focus for the lab on “omics” approaches to macrophage phenotyping and using CRISPR/Cas9 techniques to target newly identified genes for subsequent cellular and organismal phenotyping.  
This position is responsible for collaborating with the principal investigator (PI) on the design, conduct and reporting of research projects.


Job Description

Hours are generally normal business hours but may vary due to the timing of experiments and other research activity deadlines.  

Primary Duties & Responsibilities

  • Collaborates with the PI on the design, conduct and reporting of research projects.
  • Assists with grant preparation and reporting.  May submit grant proposals in rare circumstances with the approval of the PI, Department Head and Dean.
  • Prepares and submits papers on research.
  • Develops hypotheses to be tested and ways of testing it.
  • Complies with established safety procedures and maintaining required documentation on laboratory and specimen conditions.
  • Manages research projects with other institutions and investigators.

Preferred Qualifications

  • Experience with mammalian cell culture.
  • Basic microbiology skills.
  • Experience with microscopy especially confocal/fluorescence microscopy.
  • Proficiency in basic molecular biology techniques, including DNA, RNA, protein isolation and purification, PCR, cloning, reverse transcription PCR, immunoblot, ELISA.
  • Experience with immunocyto- and histo-chemistry.
  • Experience with frozen/paraffin tissue.
  • Experience with flow cytometry and immunology.
  • Ability to perform small animal procedures.
  • Experience with CRISPR/Cas9 targeting strategies, including in vitro screens.
  • Experience with RNAseq and other “omics” strategies with related bioinformatics tools to handle large data sets from RNA seq, scRNA seq, proteomics, and lipidomics experiments.  


Required Qualifications

Ph.D., M.D. or an equivalent terminal degree and at least three years of postdoctoral experience.


Grade
R12


Salary Range
$59,200.00 - $107,400.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.


Applicant Instructions
When you are ready to apply, creating an account only takes a minute. Your account creates a candidate home page which we will use to communicate with you and allows you to apply for jobs and view your application statuses. The first page of the application offers two “Quick Apply” options. Quick Apply allows you to either use a previous application or create a new application using a resume to populate the work experience and education sections of your job application. If using a resume to populate your application, check to ensure the application fields populated accurately. You may skip the “Quick Apply” page by clicking “Next” at the bottom of the page. Documents may be uploaded in the My Experience section of the application. You also have the option to apply with a Linkedin feature, which allows you to apply by using your Linkedin profile to populate some of the job application fields.

Scheduled Hours
40


Position Summary
The interest of this academic laboratory (PI:  Babak Razani) is understanding the mechanisms of atherosclerosis, diabetes, obesity, and fatty liver disease with special emphasis on the roles of macrophages.  We and others have shown that perturbations in cellular processes involving mTOR and nutrient sensing, autophagy and lysosomes, and inflammatory signaling, including inflammasomes play a critical role in macrophage dysfunction and subsequent cardiometabolic disease. Some of our relevant primary papers include (Sergin, et al Science Signaling 2016 and Sergin, et al Nature Communications 2017; Evans, et al Science Signaling 2019; Zhang, et al Nature Metabolism 2020; Jeong, et al Autophagy 2021).  The primary focus of the lab will be to understand the mechanisms by which these cellular processes affect metabolism, determine if their manipulation ameliorates metabolic disease, and translate our findings to develop novel therapeutics in human coronary artery disease, obesity, and insulin resistance. These questions are being studied using a combination of molecular and cell biology approaches in mouse primary cells/cell-lines, mouse models, human monocytes/monocyte-derived macrophages, induced pluripotent stem cell (iPSC)-derived macrophages, and circulating monocytes and tissue macrophages from humans enrolled in clinical studies. Additionally, there is a recent focus for the lab on “omics” approaches to macrophage phenotyping and using CRISPR/Cas9 techniques to target newly identified genes for subsequent cellular and organismal phenotyping.  
This position is responsible for collaborating with the principal investigator (PI) on the design, conduct and reporting of research projects.


Job Description

Hours are generally normal business hours but may vary due to the timing of experiments and other research activity deadlines.  

Primary Duties & Responsibilities

  • Collaborates with the PI on the design, conduct and reporting of research projects.
  • Assists with grant preparation and reporting.  May submit grant proposals in rare circumstances with the approval of the PI, Department Head and Dean.
  • Prepares and submits papers on research.
  • Develops hypotheses to be tested and ways of testing it.
  • Complies with established safety procedures and maintaining required documentation on laboratory and specimen conditions.
  • Manages research projects with other institutions and investigators.

Preferred Qualifications

  • Experience with mammalian cell culture.
  • Basic microbiology skills.
  • Experience with microscopy especially confocal/fluorescence microscopy.
  • Proficiency in basic molecular biology techniques, including DNA, RNA, protein isolation and purification, PCR, cloning, reverse transcription PCR, immunoblot, ELISA.
  • Experience with immunocyto- and histo-chemistry.
  • Experience with frozen/paraffin tissue.
  • Experience with flow cytometry and immunology.
  • Ability to perform small animal procedures.
  • Experience with CRISPR/Cas9 targeting strategies, including in vitro screens.
  • Experience with RNAseq and other “omics” strategies with related bioinformatics tools to handle large data sets from RNA seq, scRNA seq, proteomics, and lipidomics experiments.  


Required Qualifications

Ph.D., M.D. or an equivalent terminal degree and at least three years of postdoctoral experience.


Grade
R12


Salary Range
$59,200.00 - $107,400.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.


Applicant Instructions
When you are ready to apply, creating an account only takes a minute. Your account creates a candidate home page which we will use to communicate with you and allows you to apply for jobs and view your application statuses. The first page of the application offers two “Quick Apply” options. Quick Apply allows you to either use a previous application or create a new application using a resume to populate the work experience and education sections of your job application. If using a resume to populate your application, check to ensure the application fields populated accurately. You may skip the “Quick Apply” page by clicking “Next” at the bottom of the page. Documents may be uploaded in the My Experience section of the application. You also have the option to apply with a Linkedin feature, which allows you to apply by using your Linkedin profile to populate some of the job application fields.

Apply
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