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Postdoctoral Research Associate - Cardiology
University of Washington in Medical Lake, Washington
 
 
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Date Posted 03/03/2022
Category
Admin-Laboratory and Research
Employment Type FullTime
Application Deadline Open until filled
 
 
 
 
 

Job Description

Postdoctoral Fellow Opportunity in Cardiovascular Research.

The interest of this academic laboratory (PI:  Babak Razani) is understanding the mechanisms of atherosclerosis, diabetes, obesity, and fatty liver disease with special emphasis on the roles of macrophages.  We and others have shown that perturbations in cellular processes involving mTOR and nutrient sensing, autophagy and lysosomes, and inflammatory signaling, including inflammasomes play a critical role in macrophage dysfunction and subsequent cardiometabolic disease. Some of our relevant primary papers include (Sergin, et al Science Signaling 2016 and Sergin, et al Nature Communications 2017; Evans, et al Science Signaling 2019; Zhang, et al Nature Metabolism 2020; Jeong, et al Autophagy 2021).  The primary focus of the lab will be to understand the mechanisms by which these cellular processes affect metabolism, determine if their manipulation ameliorates metabolic disease, and translate our findings to develop novel therapeutics in human coronary artery disease, obesity, and insulin resistance. These questions are being studied using a combination of molecular and cell biology approaches in mouse primary cells/cell-lines, mouse models, human monocytes/monocyte-derived macrophages, induced pluripotent stem cell (iPSC)-derived macrophages, and circulating monocytes and tissue macrophages from humans enrolled in clinical studies. Additionally, there is a recent focus for the lab on “omics” approaches to macrophage phenotyping and using CRISPR/Cas9 techniques to target newly identified genes for subsequent cellular and organismal phenotyping. 

Hours are generally normal business hours but may vary due to the timing of experiments and other research activity deadlines.

Required Qualifications

Candidates with extensive prior experience in cell, molecular biology or related fields with a Ph.D. or M.D. degree are encouraged to apply.  

Preferred Qualifications

  • Experience in mammalian cell culture.
  • Basic microbiology skills.
  • Experience with microscopy especially confocal/fluorescence microscopy.
  • Proficiency in basic molecular biology techniques, including DNA, RNA, protein isolation and purification, PCR, cloning, reverse transcription PCR, immunoblot, and ELISA.
  • Experience with immunocyto- and histochemistry.
  • Experience with frozen/paraffin tissue.
  • Experience with flow cytometry and immunology.
  • Ability to perform small animal procedures.
  • Experience with CRISPR/Cas9 targeting strategies including in vitro screens.
  • Experience with RNAseq and other “omics” strategies with related bioinformatics tools to handle large data sets from RNA seq, scRNA seq, proteomics, and lipidomics experiments. 

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards.  The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

Interested candidates should contact Dr. Babak Razani at brazani@wustl.edu or 314-362-3688. Candidates must provide a current CV and two to three references that can be contacted directly by phone and/or email.


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

Job Description

Postdoctoral Fellow Opportunity in Cardiovascular Research.

The interest of this academic laboratory (PI:  Babak Razani) is understanding the mechanisms of atherosclerosis, diabetes, obesity, and fatty liver disease with special emphasis on the roles of macrophages.  We and others have shown that perturbations in cellular processes involving mTOR and nutrient sensing, autophagy and lysosomes, and inflammatory signaling, including inflammasomes play a critical role in macrophage dysfunction and subsequent cardiometabolic disease. Some of our relevant primary papers include (Sergin, et al Science Signaling 2016 and Sergin, et al Nature Communications 2017; Evans, et al Science Signaling 2019; Zhang, et al Nature Metabolism 2020; Jeong, et al Autophagy 2021).  The primary focus of the lab will be to understand the mechanisms by which these cellular processes affect metabolism, determine if their manipulation ameliorates metabolic disease, and translate our findings to develop novel therapeutics in human coronary artery disease, obesity, and insulin resistance. These questions are being studied using a combination of molecular and cell biology approaches in mouse primary cells/cell-lines, mouse models, human monocytes/monocyte-derived macrophages, induced pluripotent stem cell (iPSC)-derived macrophages, and circulating monocytes and tissue macrophages from humans enrolled in clinical studies. Additionally, there is a recent focus for the lab on “omics” approaches to macrophage phenotyping and using CRISPR/Cas9 techniques to target newly identified genes for subsequent cellular and organismal phenotyping. 

Hours are generally normal business hours but may vary due to the timing of experiments and other research activity deadlines.

Required Qualifications

Candidates with extensive prior experience in cell, molecular biology or related fields with a Ph.D. or M.D. degree are encouraged to apply.  

Preferred Qualifications

  • Experience in mammalian cell culture.
  • Basic microbiology skills.
  • Experience with microscopy especially confocal/fluorescence microscopy.
  • Proficiency in basic molecular biology techniques, including DNA, RNA, protein isolation and purification, PCR, cloning, reverse transcription PCR, immunoblot, and ELISA.
  • Experience with immunocyto- and histochemistry.
  • Experience with frozen/paraffin tissue.
  • Experience with flow cytometry and immunology.
  • Ability to perform small animal procedures.
  • Experience with CRISPR/Cas9 targeting strategies including in vitro screens.
  • Experience with RNAseq and other “omics” strategies with related bioinformatics tools to handle large data sets from RNA seq, scRNA seq, proteomics, and lipidomics experiments. 

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards.  The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

Interested candidates should contact Dr. Babak Razani at brazani@wustl.edu or 314-362-3688. Candidates must provide a current CV and two to three references that can be contacted directly by phone and/or email.


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

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