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Postdoctoral Research Associate - Medical Oncology
University of Washington in Medical Lake, Washington
 
 
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Date Posted 02/26/2022
Category
Admin-Laboratory and Research
Employment Type FullTime
Application Deadline Open until filled
 
 
 
 
 

Job Description

Position Summary

A postdoctoral position is available in the NIH-funded Shao lab within the Division of Oncology, Department of Medicine at Washington University School of Medicine, St. Louis, MO. The lab is part of the newly established Center of Genome Integrity and the Alvin J. Siteman Cancer Center, an NCI-designated leading cancer institute in the US (ranked 11th nationally). We are located in the state-of-the-art Couch Biochemical Research building known for its open, multi-disciplinary, and collaborative environment. As a curiosity-driven cancer biology lab, we are broadly interested in uncovering novel cancer targets with the overarching goal of improving patient outcome. Currently, we are focusing on deconvoluting complex molecular mechanisms governing genome stability and our studies center around two multi-functional proteins, the actin-binding protein Profilin-1 and the AAA+ ATPase p97/VCP. Both are essential proteins with well-known functions in the cytoplasm, but play important yet poorly understood roles in the nucleus. Our recent work (Cell Rep, 2020; Cell Rep, 2021; Cancers 2021; Front Cell Dev Biol, 2021) linked nuclear Profilin-1 and p97/VCP to fundamental cellular processes such as transcription and DNA damage response, defined their regulatory mechanisms by nucleocytoplasmic trafficking and phosphorylation, and more importantly uncovered their clinical relevance to cancer progression and therapy resistance. It is our ultimate goal that mechanistic insights from such studies can reveal hidden “Achilles heels” of cancer cells, and guide the development of novel and personalized treatments.

For more information about the lab, please visit the following websites:

  • http:// www.shaolab.org
  • https://oncology.wustl.edu/people/faculty/Shao/Shao_Bio.html
  • https://siteman.wustl.edu/research/center-for-genome-integrity/cgi-members/jieya-shao-phd/

Available Projects

  • Define the biological function of nuclear profilin-1 in DNA replication under normal and stressed conditions and its relevance to cancer chemotherapy response.
  • Understand nuclear proteostasis regulated by VCP under normal and DNA damaging conditions by identifying and characterizing novel nuclear substrates of VCP.
  • Investigate the mechanistic link between autophagy and DNA damage response.
  • Evaluate VCP as a predictive biomarker and sensitizing target for cancer chemotherapies.
  • Explore the anticancer potential of targeting nuclear export of profilin-1.

Required Qualifications

  • Highly self-motivated Ph.D. or MD/Ph.D. scientist.
  • Strong background in molecular and cellular biology.
  • Peer-reviewed, first-author publications of original findings in reputable journals.
  • Thoroughly familiar with common laboratory techniques, including cell culture, fluorescence microscopy, PCR, molecular cloning, immunoprecipitation, and Western blotting.

Preferred Qualifications

  • Computational skills and knowledge and experience in transgenic and patient-derived mouse xenograft models are highly desirable.
  • Conceptual understanding of DNA replication stress and genome integrity maintenance and related technical experience (e.g. DNA fiber and iPOND assays) are also a plus.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

Interested candidates should contact Dr. Jieya Shao by email (shao.j@wustl.edu ) with an updated CV and a cover letter containing a research statement, as well as contact information for three or more references.


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

Job Description

Position Summary

A postdoctoral position is available in the NIH-funded Shao lab within the Division of Oncology, Department of Medicine at Washington University School of Medicine, St. Louis, MO. The lab is part of the newly established Center of Genome Integrity and the Alvin J. Siteman Cancer Center, an NCI-designated leading cancer institute in the US (ranked 11th nationally). We are located in the state-of-the-art Couch Biochemical Research building known for its open, multi-disciplinary, and collaborative environment. As a curiosity-driven cancer biology lab, we are broadly interested in uncovering novel cancer targets with the overarching goal of improving patient outcome. Currently, we are focusing on deconvoluting complex molecular mechanisms governing genome stability and our studies center around two multi-functional proteins, the actin-binding protein Profilin-1 and the AAA+ ATPase p97/VCP. Both are essential proteins with well-known functions in the cytoplasm, but play important yet poorly understood roles in the nucleus. Our recent work (Cell Rep, 2020; Cell Rep, 2021; Cancers 2021; Front Cell Dev Biol, 2021) linked nuclear Profilin-1 and p97/VCP to fundamental cellular processes such as transcription and DNA damage response, defined their regulatory mechanisms by nucleocytoplasmic trafficking and phosphorylation, and more importantly uncovered their clinical relevance to cancer progression and therapy resistance. It is our ultimate goal that mechanistic insights from such studies can reveal hidden “Achilles heels” of cancer cells, and guide the development of novel and personalized treatments.

For more information about the lab, please visit the following websites:

  • http:// www.shaolab.org
  • https://oncology.wustl.edu/people/faculty/Shao/Shao_Bio.html
  • https://siteman.wustl.edu/research/center-for-genome-integrity/cgi-members/jieya-shao-phd/

Available Projects

  • Define the biological function of nuclear profilin-1 in DNA replication under normal and stressed conditions and its relevance to cancer chemotherapy response.
  • Understand nuclear proteostasis regulated by VCP under normal and DNA damaging conditions by identifying and characterizing novel nuclear substrates of VCP.
  • Investigate the mechanistic link between autophagy and DNA damage response.
  • Evaluate VCP as a predictive biomarker and sensitizing target for cancer chemotherapies.
  • Explore the anticancer potential of targeting nuclear export of profilin-1.

Required Qualifications

  • Highly self-motivated Ph.D. or MD/Ph.D. scientist.
  • Strong background in molecular and cellular biology.
  • Peer-reviewed, first-author publications of original findings in reputable journals.
  • Thoroughly familiar with common laboratory techniques, including cell culture, fluorescence microscopy, PCR, molecular cloning, immunoprecipitation, and Western blotting.

Preferred Qualifications

  • Computational skills and knowledge and experience in transgenic and patient-derived mouse xenograft models are highly desirable.
  • Conceptual understanding of DNA replication stress and genome integrity maintenance and related technical experience (e.g. DNA fiber and iPOND assays) are also a plus.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

Interested candidates should contact Dr. Jieya Shao by email (shao.j@wustl.edu ) with an updated CV and a cover letter containing a research statement, as well as contact information for three or more references.


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

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