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Postdoctoral Research Associate - Cardiology
University of Washington in Medical Lake, Washington
 
 
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Date Posted 02/18/2022
Category
Admin-Laboratory and Research
Employment Type FullTime
Application Deadline Open until filled
 
 
 
 
 

Job Description

Postdoctoral Research Associate in Ion Channel Signaling and Metabolism.

A postdoctoral fellowship position is available in the Sah Laboratory at the Washington University School of Medicine in St. Louis (Department of Medicine, Division of Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) to study the mechanisms of Transient Receptor Potential (TRP) and LRRC8a/ SWELL1 ion channel regulation and signal transduction (https://sahlab.wustl.edu ). The laboratory uses electrophysiological (e.g.  patch-clamp), imaging techniques, genetic mouse models (including CRISPR/cas9 technology), biochemical, and molecular approaches to investigate the regulation of signal transduction mechanisms of novel ion channels, including TRP/LRRC8 channels, in cardiac muscle, skeletal muscle, adipose tissue, endothelium and pancreatic beta-cells.  Broadly speaking the overarching goal of the Sah laboratory is to understand how ion channels and mechano-signaling influence cellular and organismal metabolism.  We also combine medicinal chemistry with cryo-EM structure, molecular docking, and functional studies to guide synthesis of novel ion channel modulators for the treatment of human disease.

In addition to the strong laboratory environment, the fellow will benefit from close interactions and collaborations with a dynamic ion channel community within the Department of Medicine, CIMED, the Diabetes Research Center and Cardiac Bioelectricity & Arrhythmia Center (CBAC).

St.  Louis is a mid-sized culturally rich city that maintains outstanding resources and facilities in the arts and sciences.  Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs

Required Qualifications

  • Ph.D. in the biological sciences (e.g. physiology, molecular biology, cell biology).
  • Experience in ion channel electrophysiology, imaging techniques, protein biochemistry, and an established track record of success (publications in peer-reviewed journals) OR a strong background in cell biology and protein biochemistry with an interest in learning electrophysiology and ion channel biology. 
  • Excellent oral and written communications skills.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards.  The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Application Special Instructions

To apply, send a CV, a cover letter stating research interests and qualifications, and references to rajan.sah@wustl.edu .


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

Job Description

Postdoctoral Research Associate in Ion Channel Signaling and Metabolism.

A postdoctoral fellowship position is available in the Sah Laboratory at the Washington University School of Medicine in St. Louis (Department of Medicine, Division of Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) to study the mechanisms of Transient Receptor Potential (TRP) and LRRC8a/ SWELL1 ion channel regulation and signal transduction (https://sahlab.wustl.edu ). The laboratory uses electrophysiological (e.g.  patch-clamp), imaging techniques, genetic mouse models (including CRISPR/cas9 technology), biochemical, and molecular approaches to investigate the regulation of signal transduction mechanisms of novel ion channels, including TRP/LRRC8 channels, in cardiac muscle, skeletal muscle, adipose tissue, endothelium and pancreatic beta-cells.  Broadly speaking the overarching goal of the Sah laboratory is to understand how ion channels and mechano-signaling influence cellular and organismal metabolism.  We also combine medicinal chemistry with cryo-EM structure, molecular docking, and functional studies to guide synthesis of novel ion channel modulators for the treatment of human disease.

In addition to the strong laboratory environment, the fellow will benefit from close interactions and collaborations with a dynamic ion channel community within the Department of Medicine, CIMED, the Diabetes Research Center and Cardiac Bioelectricity & Arrhythmia Center (CBAC).

St.  Louis is a mid-sized culturally rich city that maintains outstanding resources and facilities in the arts and sciences.  Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs

Required Qualifications

  • Ph.D. in the biological sciences (e.g. physiology, molecular biology, cell biology).
  • Experience in ion channel electrophysiology, imaging techniques, protein biochemistry, and an established track record of success (publications in peer-reviewed journals) OR a strong background in cell biology and protein biochemistry with an interest in learning electrophysiology and ion channel biology. 
  • Excellent oral and written communications skills.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards.  The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Application Special Instructions

To apply, send a CV, a cover letter stating research interests and qualifications, and references to rajan.sah@wustl.edu .


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

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