Postdoctoral Research Associate in Chemical Biology and Chromatin Biochemistry
The Dao laboratory at the Department of Chemical Biology and Therapeutics is seeking for a highly motivated postdoctoral research associate to conduct research at the interface of chemistry and biology. The overarching goal of the lab is to develop novel chemical and biochemical methods to manipulate and elucidate the chromatin and epigenetic processes in both normal and disease states. Our current interests include the structure and function of atypical chromatins, the molecular mechanism underlying the enhancer-promoter interaction, and protein-DNA conjugation. The first project aims to devise reconstitution methods for the assembly of physiologically relevant nucleosomes that are inaccessible
with current technologies. These chromatins will then be used to study how chromatin-modifying complexes (such as ATP-dependent chromatin remodeling complexes) recognize and act on these noncanonical structures. In the second project, the primary aim is to develop small-molecule and enzymatic tools to enable perturbations and measurements of the interaction between enhancers and the cognate promoters. I am particularly interested in technologies that allow studying chromatin dynamics at the single-cell level. The third project will focus on developing tools that enable bioconjugation of proteins and nucleic acids. These products will then be used to create platforms for DNA-barcoded screening and
methods for the delivery of biologics into cells.
The lab is well-equipped to enable hands-on training in:
- Organic synthesis of chemical probes and bioactive molecules
- Peptide synthesis
- Protein semi-synthesis and bioconjugation
- Molecular cloning and protein expression
- Protein, peptide purification, and analytics
- Complex assembly and enzymatic reactions
- Molecular biology and biophysical techniques
- Mammalian cell culture
- Genomics and proteomics
Interested candidates should have a Ph.D. in the field of biochemistry, chemical synthesis, or cell biology. Preference will be given to applicants who have received their Ph.D. degree within the last 3 years. Your primary role as a postdoctoral researcher will be to develop independent research projects with the guidance from Dr. Hai Dao. The expectation is that you will finish at least one project within 3 years. Additionally, you will have opportunities to get involved in collaborative projects within the institution. In addition to performing experiments, you will be expected to participate in writing your manuscripts and lab grants. As part of the career development plan, you are encouraged to participate in relevant conferences and training courses.
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