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Postdoctoral Research Associate in Mass Spectrometry for -Omics/Bioinformatics
Los Alamos National Security in ,
Date Posted 01/06/2022
Admin-Laboratory and Research
Employment Type
Application Deadline Open until filled

What You Will Do

The Bioenergy and Biome Sciences Group (B-11) in the Bioscience Division is seeking candidates interested in utilizing and developing proteomics, metabolomics, and/or lipidomics pipelines to deeply characterize a variety of sample types, coupled with bioinformatics utilizing data generated from high resolution platforms. Candidates skilled in handling large scale proteomics, metabolomics or lipidomics data are encouraged to apply. Experience implementing quality control standards for proteomics is strongly desired for this position; this includes the use of reference, quantitative, process control, and system performance standards. Candidates should be able to process data both quantitatively and qualitatively with and without the addition of isobaric labelling techniques. An ideal candidate will be able to work independently supporting multiple projects all of which have a National Security application. This includes but is not limited to developing improved biofuels, characterizing the molecular consequences of radiation exposure, and developing predictive exhaled human breath fingerprints. Applicants will have access to state-of-the-art high resolution mass spectrometers including multiple Orbitrap platforms, as well as access to state-of-the-art computing resources including the use of High Performance Computing resources. You will be expected to publish results in high-impact peer- reviewed journals and present your work at conferences. Los Alamos National Laboratory is a multidisciplinary, collaborative environment and we expect our Postdoctoral Fellows to exhibit this same esprit de corps.

What You Need

Minimum Job Requirements:

  • Well-established record of publications in peer-reviewed journals

  • Communication skills evidenced by reports, publications and oral presentations at conferences

  • Demonstrated experience and deep fundamental understanding of mass spectrometry with a focus on the - omics and their pipelines

  • Demonstrated hands on experience in regards to sample preparation, data acquisition, and data analysis

  • Ability to obtain a Q clearance, which typically requires US Citizenship

Education : A Ph.D. in a STEM field completed within the last five years or to be completed by commencement of appointment.

Desired Qualifications:

  • Experience handling/processing a wide range of proteomic/metabolomic data such as DDA, DIA, de-novo , top- down, etc ., including data from large scale studies

  • Ability to implement elements of quality control to account for background, extraction efficiency, quantitative precision, reproducible liquid chromatography separations, and standards/sample pools for feature identification

  • Ability to build in-house metabolite libraries and utilize publically-available resources is preferred (ex. NIST and/or MzCloud).

  • Familiarity applying machine learning and statistics to develop robust biomarker panels

  • Familiarity with harmonizing different -omics data sets for pathway analysis and correlatively studies

  • Knowledge of mass spectrometry -omics for biomarker discovery using proteomics, metabolomics, and/or lipidomics

  • Experience with the operation, maintenance, and troubleshooting of various mass spectrometers, including Thermo Fisher Orbitraps

  • Familiarity using software packages such as Proteome Discoverer 2.4, Compound Discoverer 3.2, Perseus, or MaxQuant is a plus

  • Experience with the use of robotics for sample preparation is a plus.

  • An active Q clearance

Location: This position will be located in Los Alamos, NM.

COVID Vaccine :

The COVID vaccine is mandatory for all Laboratory employees, on-site contractors, and on-site subcontractors unless granted an accommodation under applicable state or federal law. This requirement will apply to those working on-site, those teleworking, and all new hires.

Note to Applicants:

This position is a two yearappointment with a third year contingent upon excellent performance. Exceptional candidates may be considered for a Director's Fellowship and outstanding candidates may be considered for the prestigious Dianne Christian Hoffman, Richard P. Feynman, J. Robert Oppenheimer, or Frederick Reines Fellowships. For general information about the Postdoc Program, including salary guidelines, go to:

https://www.lanl.gov/careers/career-options/postdoctoral-research/index.php .

In addition to applying online on the LANL jobs site, qualified candidates can email a copy of your CV and cover letter, or any questions to Trevor Glaros (tglaros@lanl.gov). The candidates will be expected to obtain DOE Q clearance during the fellowship, which normally requires US citizenship.

Where You Will Work

Teams within the Bioscience Division at Los Alamos National Laboratory (LANL) perform research in a broad array of applications of biotechnology and life sciences, working to solve national bioenergy and biosecurity challenges —from naturally occurring or manmade threats—requiring an in-depth understanding of pathogens, plants, and human disease.

Located in beautiful northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security. Our generous benefits package includes:

§ PPO or High Deductible medical insurance with the same large nationwide network

§ Dental and vision insurance

§ Free basic life and disability insurance

§ Paid childbirth and parental leave

§ Award-winning 401(k) (6% matching plus 3.5% annually)

§ Learning opportunities and tuition assistance

§ Flexible schedules and time off (paid sick, vacation, and holidays)

§ Onsite gyms and wellness programs

§ Extensive relocation packages (outside a 50 mile radius)

Additional Details

Directive 206.2-Employment with Triad requires a favorable decision by NNSA indicating employee is suitable under NNSA Supplemental Directive 206.2 . Please note that this requirement applies only to citizens of the United States. Foreign nationals are subject to a similar requirement under DOE Order 142.3A.

Q Clearance: Applicants selected will be subject to a Federal background investigation and must meet eligibility requirements

  • for access to classified matter. This position requires a Q clearance which requires US Citizenship except in extremely rare circumstances. Dependent upon position, additional authorization to access nuclear weapons information may be required that may or may not be available to dual citizens depending upon the circumstances.

  • Eligibility requirements: To obtain a clearance, an individual must be at least 18 years of age; U.S. citizenship is required except in very limited circumstances. See DOE Order 472.2 for additional information.

New-Employment Drug Test: The Laboratory requires successful applicants to complete a new-employment drug test and maintains a substance abuse policy that includes random drug testing.

Equal Opportunity: Los Alamos National Laboratory is an equal opportunity employer and supports a diverse and inclusive workforce. All employment practices are based on qualification and merit, without regard to race, color, national origin, ancestry, religion, age, sex, gender identity, sexual orientation or preference, marital status or spousal affiliation, physical or mental disability, medical conditions, pregnancy, status as a protected veteran, genetic information, or citizenship within the limits imposed by federal laws and regulations. The Laboratory is also committed to making our workplace accessible to individuals with disabilities and will provide reasonable accommodations, upon request, for individuals to participate in the application and hiring process. To request such an accommodation, please send an email to applyhelp@lanl.gov or call 1-505-665-4444 option 1. Employment Status

Full Time

Appointment Type



Contact Details
Contact Name
Work Telephone
Vacancy Name: IRC96834
Organization Name B-11/Bioenergy and Biome Sciences
Minimum Salary
Maximum Salary
Req ID: IRC96834
Category: Postdoc

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