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Research Specialist, Molecular Assay Development - Haber Lab
HHMI in ,
 
 
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Date Posted 12/24/2021
Category
Admin-Laboratory and Research
Employment Type FullTime
Application Deadline Open until filled
 
 
 
 
 

Primary Work Address: 50 Blossom Street, Boston, MA, 02114


Current HHMI Employees, click here to apply via your Workday account.

We are currently seeking a Research Specialist within the lab of Dr. Daniel Haber at Massachusetts General Hospital in Boston.
The Haber lab focuses on understanding mutations that are acquired by tumors and render them susceptible to specific targeted drug therapies. They have identified mutations in the EGFR gene in lung cancers which confer dramatic sensitivity to drugs that specifically inhibit that pathway. This finding triggered the application of targeted therapies in lung cancer, and more generally pointed to the critical importance of mutational analysis for treatment selection in common epithelial cancers. Since then, they have collaborated with the bioengineering team led by Dr. Mehmet Toner, the molecular biology group of Dr. Shyamala Maheswaran, and the MGH Cancer Center clinical disease centers to develop, characterize, and apply microfluidic devices to isolate rare circulating tumor cells (CTCs) in the blood of patients with cancer. Using these technologies, the Haber lab seeks to explore:

  • Blood-based early detection of cancer

  • Noninvasive monitoring of cancer for the emergence of drug resistance

  • Understanding mechanisms of tumor cell dissemination and metastasis, with the ultimate goal of suppressing blood-borne spread of cancer.


More information about the lab can be found on their website .

As the Research Specialist, you will work collaboratively with the team to develop assays to detect and characterize CTCs with the aim to develop new tools for early detection of cancer and monitoring response to therapy. We are looking for a strong scientist with significant experience in the realm of cancer biology who is interested in contributing to the lab’s research goals and can ideally commit to a long-term working relationship to learn the technology, build up a repository of knowledge, and partner with postdoctoral associates and other lab team members for project activities.

You will have the opportunity to have your research published, attend conferences, seminars, and other professional development events, and be a part of both the HHMI and Massachusetts General Hospital community – Massachusetts General is home to the largest hospital-based research program in the United States and is the oldest and largest teaching hospital of Harvard Medical School.

Primary Responsibilities

  • Develop molecular assays in order to detect and characterize CTCs using both microscopic imaging and sequencing-based approaches.

  • Work collaboratively with other scientists across different disciplines including bioengineering, microfluidics, and clinical medicine.

  • Supervise and train research technicians allocated to the project.  

  • Stay current on all relevant literature and techniques.

  • Participate in weekly laboratory meetings, sub-group meetings, and planning sessions.

You Have

  • A Bachelor's degree (Master’s degree strongly preferred, PhD would be a plus) in the biological sciences.

  • Ideally 3+ years of cancer biology-focused research experience.

  • Experience with molecular biology techniques including next-generation sequencing (NGS), imaging, and cell culture.

  • The ability to perform complex experiments with high reliability and accuracy with minimal supervision.

  • Excellent organizational, communication and time management skills.

  • Excellent leadership and training skills.

  • An enthusiasm for exploring new areas of science, with a deep desire to develop novel solutions.

You Are

  • Detail-oriented, self-motivated, proactive, and efficient.

  • A creative problem solver who is excited about the laboratory’s research and open to collaborating with a wide variety of people at all levels to accomplish goals.

  • Capable of working both independently and within a larger team.

  • Capable of supervising technicians and mentoring their scientific development.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.


HHMI is an Equal Opportunity Employer

Primary Work Address: 50 Blossom Street, Boston, MA, 02114


Current HHMI Employees, click here to apply via your Workday account.

We are currently seeking a Research Specialist within the lab of Dr. Daniel Haber at Massachusetts General Hospital in Boston.
The Haber lab focuses on understanding mutations that are acquired by tumors and render them susceptible to specific targeted drug therapies. They have identified mutations in the EGFR gene in lung cancers which confer dramatic sensitivity to drugs that specifically inhibit that pathway. This finding triggered the application of targeted therapies in lung cancer, and more generally pointed to the critical importance of mutational analysis for treatment selection in common epithelial cancers. Since then, they have collaborated with the bioengineering team led by Dr. Mehmet Toner, the molecular biology group of Dr. Shyamala Maheswaran, and the MGH Cancer Center clinical disease centers to develop, characterize, and apply microfluidic devices to isolate rare circulating tumor cells (CTCs) in the blood of patients with cancer. Using these technologies, the Haber lab seeks to explore:

  • Blood-based early detection of cancer

  • Noninvasive monitoring of cancer for the emergence of drug resistance

  • Understanding mechanisms of tumor cell dissemination and metastasis, with the ultimate goal of suppressing blood-borne spread of cancer.


More information about the lab can be found on their website .

As the Research Specialist, you will work collaboratively with the team to develop assays to detect and characterize CTCs with the aim to develop new tools for early detection of cancer and monitoring response to therapy. We are looking for a strong scientist with significant experience in the realm of cancer biology who is interested in contributing to the lab’s research goals and can ideally commit to a long-term working relationship to learn the technology, build up a repository of knowledge, and partner with postdoctoral associates and other lab team members for project activities.

You will have the opportunity to have your research published, attend conferences, seminars, and other professional development events, and be a part of both the HHMI and Massachusetts General Hospital community – Massachusetts General is home to the largest hospital-based research program in the United States and is the oldest and largest teaching hospital of Harvard Medical School.

Primary Responsibilities

  • Develop molecular assays in order to detect and characterize CTCs using both microscopic imaging and sequencing-based approaches.

  • Work collaboratively with other scientists across different disciplines including bioengineering, microfluidics, and clinical medicine.

  • Supervise and train research technicians allocated to the project.  

  • Stay current on all relevant literature and techniques.

  • Participate in weekly laboratory meetings, sub-group meetings, and planning sessions.

You Have

  • A Bachelor's degree (Master’s degree strongly preferred, PhD would be a plus) in the biological sciences.

  • Ideally 3+ years of cancer biology-focused research experience.

  • Experience with molecular biology techniques including next-generation sequencing (NGS), imaging, and cell culture.

  • The ability to perform complex experiments with high reliability and accuracy with minimal supervision.

  • Excellent organizational, communication and time management skills.

  • Excellent leadership and training skills.

  • An enthusiasm for exploring new areas of science, with a deep desire to develop novel solutions.

You Are

  • Detail-oriented, self-motivated, proactive, and efficient.

  • A creative problem solver who is excited about the laboratory’s research and open to collaborating with a wide variety of people at all levels to accomplish goals.

  • Capable of working both independently and within a larger team.

  • Capable of supervising technicians and mentoring their scientific development.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.


HHMI is an Equal Opportunity Employer

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