Research in the Ash lab is focused on developing a deep understanding of retinal diseases causing blindness and then using this knowledge to develop new therapies to prevent them. The first project seeks to uncover the role of dysregulated mitochondrial function in retinal degeneration and the discovery of new therapeutic targets. The project studies the role of AMPK in regulating retinal metabolism in health and disease. The second project seeks to identify inflammation and the integrated stress responses transcriptional networks that regulate retinal degeneration in mammals and regeneration in fish. Both projects use hypothesis-driven studies combined with discovery-based multi-omic approaches.
Ideal candidates will have a Ph.D. in biochemistry, cell biology, neuroscience, or bioinformatics, and strong written and verbal communication skills. A 2.5-year minimum commitment and qualification to apply for an F32 or K99/R00 grant application are required.
These projects require work with rodent models of retinal degeneration, retinal structure and function characterization by optical coherence tomography and electroretinography, gene expression analysis by RT-qPCR and RNAseq, and protein expression by Western blots. The work also requires extensive data analysis, including integrating data from RNA-seq, ChIP-seq, proteomics, and metabolomics.
|Special Instructions to Applicants:
Qualified candidates should submit a cover letter describing an interest in the position and relevant experience, curriculum vitae, research statement and contact information for the three references. If preferred, reference letters can be addressed to John Ash, Ph.D., Associate Professor, Department of Ophthalmology.
Final candidate will be required to provide official transcript to the hiring department upon hire. A transcript will not be considered “official” if a designation of “Issued to Student” is visible. Degrees earned from an education institution outside of the United States are required to be evaluated by a professional credentialing service provider approved by National Association of Credential Evaluation Services (NACES), which can be found at http://www.naces.org/ .
The University of Florida is An Equal Employment Opportunity Institution. If an accommodation due to a disability is needed to apply for this position, please call 352/392-2477 or the Florida Relay System at 800/955-8771 (TDD). Hiring is contingent upon eligibility to work in the US. Searches are conducted in accordance with Florida's Sunshine Law.
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Application must be submitted by 11:55 p.m. (ET) of the posting end date.