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Postdoctoral Fellow
Rutgers University in New Brunswick, New Jersey
 
 
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Date Posted 11/04/2021
Category
Admin-Other Administrative Positions
Employment Type
Application Deadline Open until filled
 
 
 
 
 

Position Details
Recruitment/Posting Title Postdoctoral Fellow
Job Category Staff & Executive - Research (Laboratory/Non-Laboratory)
Department NJMS-Emergen Pathogen Affil
Overview
New Jersey’s academic health center, Rutgers Biomedical and Health Sciences (RBHS) takes an integrated approach to educating students, providing clinical care, and conducting research, all with the goal of improving human health. Aligned with Rutgers University–New Brunswick and collaborating university wide, RBHS includes eight schools, a behavioral health network, and six centers and institutes that focus on cancer treatment and research, neuroscience, clinical and translational research, advanced biotechnology and medicine, environmental and occupational health, and health care policy and aging research. 
Our faculty are teachers, clinicians, and scientists with unparalleled experience who advance medical innovation and provide patient care informed by the latest research findings. We offer an outstanding education in medicine, dentistry, pharmacy, public health, nursing, biomedical research, and the full spectrum of allied health careers.
Our clinical and academic facilities are located throughout the state including New Brunswick, Piscataway, Newark, Scotch Plains, Somerset, Blackwood, and other locations.  Clinical partners include Robert Wood Johnson University Hospital in New Brunswick, University Hospital in Newark, and other affiliates.
Through this community of healers, scientists, and scholars, Rutgers is equipped as never before to transform lives.
Rutgers RBHS is an anchor institution that boasts locations in Newark, New Jersey, a city of promise.
Posting Summary
Rutgers, The State University of New Jersey is seeking a Research Associate III for the Department of Microbiology, Biochemistry, and Molecular Genetics within the New Jersey Medical School.  Under the direction of the Principal Investigator (PI), the Postdoctoral Fellow will investigate the cell biology underlying interactions between macrophages and Mycobacterium tuberculosis. The major focus will be understanding how post-translational modifications of host proteins impact the initiation, progression, and resolution of key innate immune pathways like cytosolic DNA sensing and selective autophagy. In addition, proteomics approaches and genetic screens will be employed to identify novel players in these pathways, including host proteins and bacterial factors. Validation of both previously identified and newly discovered factors will be performed using a combination of M. tuberculosis genetics (knockout and complemented strains, transposon screens, etc.), macrophage genetics (CRISPR knockout macrophages, epitope-tagged expression lines, mammalian CRISPR screens, etc.), biochemistry (immunoprecipitations, mass spectrometry, ubiquitination/phosphorylation assays, etc.), molecular biology (RT-qPCR, RNA-seq, etc.), cell biology (immunofluorescence, protein studies/western blots, etc.), and mouse infection models. The work from these studies will deepen our understanding of the molecular interface between the host macrophage and intracellular M. tuberculosis, promoting the development of more effective therapies to treat TB. 
Among the key duties of this position are the following:
  •  Characterize the ex vivo response to M. tuberculosis in macrophages.
  • Characterize the in vivo response to M. tuberculosis in a low dose aerosol mouse model of infection.
  • Design, optimize, perform, and analyze M. tuberculosis transposon screens.
  • Generate M. tuberculosis knockouts, complements, and other strains necessary for experiments.
  • Design, optimize, perform, and analyze CRISPR screens in primary macrophages and macrophage cell lines.
  • Generate CRISPR knockouts of one or more genes in macrophages. 
Position Status Full Time
Hours Per Week
Daily Work Shift Day
FLSA Exempt
Grade 99S
Position Salary 55,000
Annual Minimum Salary
Annual Mid Range Salary
Annual Maximum Salary
Standard Hours 37.50
Union Description Non-Union
Payroll Designation PeopleSoft
Benefits

Information about the benefits provided to Rutgers employees can be found at: http://uhr.rutgers.edu/benefits/benefits-overview

Seniority Unit
Terms of Appointment Temporary Staff Appointment - Salaried 12 Month
Position Pension Eligibility None

Minimum Education and Experience
  • Doctoral Degree in microbiology, cell biology, biochemistry, molecular biology, immunology, or a related relevant science. 
Certifications/Licenses
Required Knowledge, Skills, and Abilities
Preferred Qualifications
  • Experience includes independently designing and executing host-pathogen interaction studies, performing unsupervised work in the BSL3 on M. tuberculosis, analyzing next generation sequencing dataset, and using high-throughput automated imaging approaches.
Equipment Utilized
Physical Demands and Work Environment
  • This position involves prolonged standing, walking and sitting, as well as use of laboratory equipment.
  • Must perform complex procedures and demonstrate manual dexterity.
  • Some stooping, reaching, climbing and bending. Occasional lifting of 20 pounds to a height of 6½ feet. 

 
Special Conditions
  • Must be available to work flexible hours including weekends and holidays when necessary to meet deadlines. Must be willing to work with small animals. 

Posting Number 21ST3543
Posting Open Date
Special Instructions to Applicants
Regional Campus Rutgers Biomedical and Health Sciences (RBHS)
Home Location Campus Newark (RBHS)
Location Details




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