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Postdoctoral Fellow
Rutgers University in New Brunswick, New Jersey
 
 
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Date Posted 07/14/2021
Category
Admin-Other Administrative Positions
Employment Type
Application Deadline Open until filled
 
 
 
 
 

Position Details


Recruitment/Posting Title Postdoctoral Fellow
Job Category Staff & Executive - Research (Laboratory/Non-Laboratory)
Department NJMS-Medicine-Infectious Diseases
Overview
New Jersey’s academic health center, Rutgers Biomedical and Health Sciences (RBHS) takes an integrated approach to educating students, providing clinical care, and conducting research, all with the goal of improving human health. Aligned with Rutgers University–New Brunswick and collaborating university-wide, RBHS includes eight schools, a behavioral health network, and five centers and institutes that focus on cancer treatment and research, neuroscience, advanced biotechnology and medicine, environmental and occupational health, and health care policy and aging research.
Our faculty are teachers, clinicians, and scientists with unparalleled experience who advance medical innovation and provide patient care informed by the latest research findings. We offer an outstanding education in medicine, dentistry, pharmacy, public health, nursing, biomedical research, and the full spectrum of allied health careers.
Our clinical and academic facilities are located throughout the state—at Rutgers University–New Brunswick, including Piscataway; and at locations in Newark, Scotch Plains, Somerset, Stratford, and other locations. Clinical partners include Robert Wood Johnson University Hospital in New Brunswick, Newark’s University Hospital in Newark, and other affiliates. Through this community of healers, scientists, and scholars, Rutgers is equipped as never before to transform lives.
 Rutgers RBHS is an anchor institution that boasts locations in Newark, New Jersey, a city of promise.
Posting Summary
Rutgers, The State University of New Jersey is seeking a Postdoctoral Fellow for the Department of Medicine within the New Jersey Medical School.  Under the direction of the Principal Investigator, the Postdoctoral Fellow will investigate the molecular basis of how two Mycobacterium tuberculosis proteins, Rv2623 (a universal stress protein (USP)) and Rv1747 (a putative exporter of lipooligosaccharides) interact to regulate the export of phosphatidyl-myo-inositol mannosides (PIM), immunoregulatory cell wall glycolipids of the tubercle bacillus, thereby influencing anti-TB immunity and modulating in vivo growth of M. tuberculosis. A combination of genetic, biochemical, and immunological approaches, together with various murine experimental tuberculosis models, will be employed to elucidate how the Rv2623-Rv1747-PIM pathway regulate M. tuberculosis growth in the host. The results yielded from the study may illuminate the mechanisms involved in how the growth of M. tuberculosis is regulated in vivo, including in the context of tuberculous latency and reactivation and may lead to the development of anti-TB therapies.
Among the key duties of this position are the following:
  • Generate point mutations of specific genes in M tuberculosis by allelic exchange using the mycobacteriophage-based specialized transduction and site-directed mutagenesis technology.
  •  Conditional knockdown of genes of interest in M. tuberculosis.
  • M. tuberculosis protein-protein interaction assays.
  • Expression and biochemical characterization of M. tuberculosis proteins.
  • Characterization of the in vitro growth kinetics of various M. tuberculosis mutants.
  • Characterization of the in vivo growth kinetics of various M. tuberculosis mutants in a low dose aerosol infection tuberculosis mouse model. 
Position Status Full Time
Hours Per Week
Daily Work Shift Day
FLSA Exempt
Grade 99S
Position Salary 55000
Annual Minimum Salary
Annual Mid Range Salary
Annual Maximum Salary
Standard Hours 37.50
Union Description Non-Union
Payroll Designation PeopleSoft
Benefits

Information about the benefits provided to Rutgers employees can be found at: http://uhr.rutgers.edu/benefits/benefits-overview

Seniority Unit
Terms of Appointment Staff - 12 month
Position Pension Eligibility None

Minimum Education and Experience
  • Doctoral Degree in relevant science.
Certifications/Licenses
Required Knowledge, Skills, and Abilities
Preferred Qualifications
  • Experience includes independent design and conduction of genetic and microbiological studies, experience performing unsupervised work in the BSLIII on M. tuberculosis, ability to analyze next generation DNA sequencing data. 
  • Experience in automated, high-throughput fluidic studies of bacterial growth. 
Equipment Utilized
Physical Demands and Work Environment
  • This position involves prolonged standing, walking and sitting, as well as use of laboratory equipment. Must perform complex procedures and demonstrate manual dexterity.
  • Occasional lifting of 20 pounds to a height of 6½ feet.
  • Hearing and speech capabilities necessary to communicate with other researchers and staff in person, on the telephone and by e-mail.
  • Vision capable of viewing gauges, computer monitors, charts, forms, text and numbers for prolonged periods. 
Special Conditions
  • To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. This includes training in BSL3 practices, and willingness to work with virulent and drug-resistant M. tuberculosis.
  • The requirements listed must be representative of the knowledge, skills, minimum education, training, licensure, experience, and/or ability required.
  • Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Posting Number 21ST1888
Posting Open Date
Special Instructions to Applicants
Regional Campus Rutgers Biomedical and Health Sciences (RBHS)
Home Location Campus Newark (RBHS)
Location Details




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