Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has commercially launched Guardant360, Guardant360 CDx, Guardant360 TissueNext, Guardant360 Response, and GuardantOMNI tests for advanced stage cancer patients, and Guardant Reveal for early-stage cancer patients. The Guardant Health screening portfolio, including the Shield test, aims to address the needs of individuals eligible for cancer screening.

About the Role:

The Bioinformatics Scientist II will join an interdisciplinary team working with an unprecedented set of clinical DNA whole genome and exome sequence data and multiple epigenetic data types produced by novel R&D pipelines at Guardant Health. The scope of this project provides unique opportunities for developing and learning novel analytical methods for DNA sequencing data, including cell free DNA-based transcript expression and methylation data integrated with epigenetic data sets.

Essential Duties and Responsibilities:

• Work with large, complex data sets. Tend to non-routine analysis problems, applying deep epigenetic knowledge to conduct end-to-end analysis of epigenetic cell-free nucleic acid NGS data.

• Development, continuous improvement, and validations of novel biomarkers for Guardant Health oncology products.

• Develop or apply statistical methods and procedures to evaluate and validate Guardant Health technologies.

• Work with the Technology Development team to develop and analyze verification and validation experiments as part of regulatory submissions.

• Provide analytic support on individual samples and research activities.

• Develop scripts for research and development activities, and leverage cutting edge AI methods to continuously improve efficiency.

• Communicate research results through presentations and project reports as well as scientific publications.

• Ph.D. in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Cancer Biology, Genetics, Genomics, Computer Science

• 1-3 years of experience

Work Environment:

• Employee may be required to lift routine office supplies and use office equipment.

• Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment.

• Ability to sit for extended periods of time.

• Proven scientific reputation as demonstrated by scientific publication and/or contribution to successful product development in the biotech industry.

• Deep understanding of modern tools and pipelines in genomics for processing and analysis of primary data, including somatic and structural variant calling.

• Experience with next generation sequencing data analysis (DNA, RNA, or epigenetic analysis).

• Deep experience with a statistical programming language (e.g., R, python).

• Demonstrated effective written and verbal communication skills.

Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays.We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $124,200 to $167,700. The range does not include benefits, and if applicable, bonus, commission, or equity

The US base salary range for this full-time position is $93,200 to$149,100. The range does not include benefits, and if applicable, bonus, commission, or equity.The range displayed reflects the minimum and maximum target for new hire salaries across all US locations for the posted role with the exception of any locations specifically referenced below (if any).

Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above.

Employee may be required to lift routine office supplies and use office equipment.Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment.Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out toPeopleteam@guardanthealth.com

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review ourPrivacy Notice for Job Applicants.

Please visit our career page at:http://www.guardanthealth.com/jobs/

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