City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
A Postdoctoral Fellow Position is available to probe the mechanisms of alcohol use disorders. In the U.S., this chronic relapsing brain disorder is estimated to occur in 15 million people. The resulting pattern of long-term alcohol use can lead to cancer and diabetes; it may limit the life span of an individual by more than 20 years. Unfortunately, current treatments for alcohol use disorders are inadequate. Jovanovic-Talisman laboratory has been probing the disorder at the molecular level: We develop new methods to perform quantitative single molecule localization microscopy (qSMLM). This super-resolution imaging technique allows us to detect individual molecules in cells and biospecimens. We have been using qSMLM to assess how alcohol perturbs the dynamic organization of signaling domains that harbor opioid receptors (ACS Chemical Neuroscience, 2019, Tobin et al.). The NIH funded Postdoctoral Fellow will probe the nano-organization of kappa and mu opioid receptors in cultured cells and rat brains.
Key Responsibilities include:
Acute exposure to ethanol affects both the clustering and nano-organization of opioid receptors. However, this effect is largely impeded by the drug naltrexone. To probe this mechanism further and to assess new therapeutics, we seek a Postdoctoral Fellow to design and execute studies that comprise some of the following activities: cell culture, plasmid transfection, antibody labeling and validation; immunostaining of cells and rat brain slices; qSMLM imaging and data analysis; development of new codes (MATLAB) to process qSMLM data.
Basic education, experience and skills required for consideration:
A Ph.D. degree in biomedical sciences, biophysics, chemical engineering or a related discipline is required with no more than 3 years of postdoctoral training.
Experience in quantitative microscopy, cell biology, and MATLAB programing.
Ability to carry out independent research and prepare manuscripts for publication.
Super-resolution microscopy experience is highly preferred.
About Dr. Jovanovic-Talisman: Tijana Jovanovic-Talisman, PhD is an Associate Professor in the Department of Molecular Medicine. Dr. Talisman and team are investigating biological processes that are critical to the progression of cancer and other diseases by using quantitative single molecule localization microscopy (qSMLM).
For more information on the Jovanovic-Talisman Lab, please click here.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.