There is an exciting new opportunity at the University of Southern California for highly motivated Postdoctoral candidate committed to developing a successful career in chromatin biology or stem cell biology. Our lab has extensive expertise and excellent track record in studying epigenetic regulations of cell fate determination using embryonic stem cell, or cancer cell as the model. We employ multidisciplinary approaches to understand the functions of histone modifying enzymes e.g. MLL and MOF, in a variety of physiological and pathological processes.
Responsibilities include a) Developing novel approaches to characterize epigenomes in stem cells and cancer cells, b) Conducting cellular, molecular and in vivo experiments for hypothesis-driven research, and c) Preparing presentations and publishing scientific manuscripts under the direction of the Principal Investigator. Candidate will enjoy a highly collaborative environment in Dou lab as well as USC research community. It is essential that the applicant has excellent organizational and communication skills. The postdoctoral trainees will be encouraged to submit their own fellowship and grant applications during their periods of training.
Interested candidates should send a CV to Dr. Dou (firstname.lastname@example.org ), Professor of Medicine and Co-leader of the Genomic and Epigenomic Regulation Program in the USC/Norris Comprehensive Cancer Center.
Representative publications (2018-2021):
Histone acetyltransferase MOF regulates quiescence in ground-state pluripotency through fatty acid oxidation. Cell Stem Cell , 27(3):441-458, 2020.
Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome. Nature Communication , 10(1):5540. doi: 10.1038/s41467-019-13550-2, 2019.
Facile target validation in an animal model using monobodies. Nature Chemical Biology , 14(9), 895-900, 2018.
HOXA9 reprograms the enhancer landscape during leukemic transformation. Cancer Cell , 34, 643-658, 2018.
Preferred Education:PhDin Molecular and Cellular Biology, Genetics, Developmental Biology, or in a relevant field
Preferred Experience:Experience with standard molecular and cellular biology techniques and familiarity with genomic technologies are essential. Experience in performing epigenomic assays (CRISPR/Cas9, ChIP, ATAC-, 4C-seq) will be a plus but not required. The ability to learn new techniques quickly and a strict attention to details of experimental protocols are required.
Preferred Field of Expertise:Leukemia, embryonic stem cells, cancer epigenetics
Percentage of Time:100%
Fixed Term: 04/01/2021-06/30/2022
Minimum Education: Ph.D. or equivalent doctorate within previous five years
Minimum Experience: 0-1 year
Minimum Field of Expertise: Directly related education in research specialization with advanced knowledge of equipment, procedures and analysis methods. Strong background in computer programming, mathematical modeling is required.