This is a full-time, fixed term position.
The laboratory of Oliver Bell at the Departments of Biochemistry and Molecular Medicine, and Stem Cell and Regenerative Medicine of the Keck School of Medicine of USC is looking for highly motivated, creative postdoctoral fellows with a strong background in molecular biology, genomics and computational data analysis, as well as skills culturing mouse/human embryonic stem cells.
Our lab is interested in elucidating the mechanisms of epigenetic gene silencing by Polycomb and HP1-dependent heterochromatin which play a critical role in maintaining developmental cell fate decisions. Besides state-of-the-art genetic, genomic and biochemical approaches, we apply cutting-edge biosynthetic technologies and develop small molecule inhibitors to reversibly control and directly interrogate the function of epigenetic heterochromatin modifiers in gene regulation. In collaboration with chemical biologists and clinicians we aim to identify novel epigenetic targets and develop innovate therapeutic strategies for disease including cancer and neurodevelopmental disorders.
Funding for the position is guaranteed for up to three years. For more information, check out our website at https://belllab.usc.edu/ and publications listed below. Interested candidates, please apply by completing the application in Workday
and contacting Oliver Bell (firstname.lastname@example.org) with a brief statement of interest, your CV and contact information of 2-3 references.
Zepeda-Martinez JA, Pribitzer C, Wang J, Burkard TR, Reichholf B, Bsteh D, Rhie SK, Jude J, Moussa HF, Zuber J, Bell O. Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self- renewal in mouse embryonic stem cells. Science Advances . 2020 April 1.
Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey I, Norris1 JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O*, and Frye SV*. Discovery and Characterization of a Cellularly Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Aug 14
Moussa HF, Bsteh D, Yelagandula R, Pribitzer C, Stecher K, Bartalska K, Michetti L, Wang J, Zepeda-Martinez JA, Elling U, Stuckey JI, James LI, Frye SC, Bell O. Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Nat Commun . 2019 Apr 29;10(1):1931.
Hathaway N, Bell O, Hodges C, Miller E, Neel D, Crabtree G. Dynamics and Memory of Heterochromatin in Living Cells. Cell . 2012 June; 149(7):1447-1460.
Minimum education: Ph.D. or equivalent doctorate within previous three years
Minimum experience: 0-1 year
Minimum field of expertise: Directly related education in research specialization with advanced knowledge of equipment, procedures and analysis methods.