The Ludwig Center for Metastasis Research, led by Dr. Ralph Weichselbaum, brings together researchers with various expertise, including molecular and cell biology, bioinformatics, chemistry, genetics, imaging and medicine to dissect tumor and host factors that limit metastasis and develop novel methods of treatment of metastasis, including radiotherapy in combination with immunological approaches, nano formulations, and the microbiome. The Bishop and Connell Labs study the mechanism of homologous repair, with a particular focus on Rad51 and Dmc1. The investigations considers how Dmc1's function is specialized for meiosis, how the functions of Rad51 and Dmc1 differ, and how these proteins interact. The Center for Electron Paramagnetic Resonance (EPR) Imaging in Vivo Physiology, led by Dr. Howard Halpern, aims to create new imaging technologies in order to better visualize the tissues of living animals. The EPR imaging technology under development by the Center has powerful implications for the treatment of cancers, strokes, peripheral vascular diseases and heart attacks.
The job facilitates and promotes a research project or contributes to the scientific direction of a research resource. Receives a moderate level of guidance and direction.
- Lead the development and functional characterization of CAR-T cells.
- Coordinate the experimental work with colleagues in the Weichselbaum and Kossiakoff lab.
- Supervise and mentor students and technicians to execute in-vitro and in vivo studies to assess CAR-T cell anti-tumor efficacy and safety using mouse models.
- Maintain detailed records of experimental protocols and results.
- Stay up to date on the latest scientific and technological advancements in the field of immune cell engineering.
- Develop in-vitro functional assays for screening of chimeric antigen receptors.
- Collaborate with faculty on manuscript and grant writing, data analysis, and presenting findings at conferences.
- Serves as a resource for collecting data and performing analysis. Contributes to facilitating and promoting a research project by providing scientific or intellectual information.
- Reviews laboratory protocols and training on new techniques. Manage complex data sets for research.
- Leads the contributions to scientific writing and publications, including protocols and grants.
- Trains new laboratory personnel.
- Performs other related work as needed.
Minimum requirements include a PhD in related field.
Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.
- Ph.D. in a biochemistry area or related field.
- strong experience in tissue culture (BSL2), protein expression in human cell lines, stable cell line generation, lentivirus, and retrovirus transduction.
- Experience in engineering human T cells, experience in phage display mutagenesis, and fluorescent microscopy techniques.
- Experience in mentoring students is important.
- Hands-on proficiency in primary immune cell isolation, culture, phenotypic and functional characterization of immune cells required.
- Hands-on experience with in vitro and ex vivo functional assays of primary human T cells, T cell killing assays, cytokine assays required
- Experience on human signal transduction and protein-protein interaction assays required.
- Ability to work independently and as a part of team.
- Ability to work with animal in the research lab.
- Ability to train others.
- Resume (required)
- Three references (required)
When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Resume/CV of the application.
Scheduled Weekly Hours
Drug Test Required
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