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Research Professional
The University of Chicago in Chicago, Illinois
 
 
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Date Posted 04/05/2021
Category
Science-Biochemistry
Employment Type Fulltime
Application Deadline Open until filled
 
 
 
 
 

The Ludwig Center for Metastasis Research, led by Dr. Ralph Weichselbaum, brings together researchers with various expertise, including molecular and cell biology, bioinformatics, chemistry, genetics, imaging and medicine to dissect tumor and host factors that limit metastasis and develop novel methods of treatment of metastasis, including radiotherapy in combination with immunological approaches, nano formulations, and the microbiome. The Bishop and Connell Labs study the mechanism of homologous repair, with a particular focus on Rad51 and Dmc1. The investigations considers how Dmc1's function is specialized for meiosis, how the functions of Rad51 and Dmc1 differ, and how these proteins interact. The Center for Electron Paramagnetic Resonance (EPR) Imaging in Vivo Physiology, led by Dr. Howard Halpern, aims to create new imaging technologies in order to better visualize the tissues of living animals. The EPR imaging technology under development by the Center has powerful implications for the treatment of cancers, strokes, peripheral vascular diseases and heart attacks.


Job Summary

The job facilitates and promotes a research project or contributes to the scientific direction of a research resource. Receives a moderate level of guidance and direction.

Responsibilities

  • Lead the development and functional characterization of CAR-T cells.
  • Coordinate the experimental work with colleagues in the Weichselbaum and Kossiakoff lab.
  • Supervise and mentor students and technicians to execute in-vitro and in vivo studies to assess CAR-T cell anti-tumor efficacy and safety using mouse models.
  • Maintain detailed records of experimental protocols and results.
  • Stay up to date on the latest scientific and technological advancements in the field of immune cell engineering.
  • Develop in-vitro functional assays for screening of chimeric antigen receptors.
  • Collaborate with faculty on manuscript and grant writing, data analysis, and presenting findings at conferences.
  • Serves as a resource for collecting data and performing analysis. Contributes to facilitating and promoting a research project by providing scientific or intellectual information.
  • Reviews laboratory protocols and training on new techniques. Manage complex data sets for research.
  • Leads the contributions to scientific writing and publications, including protocols and grants.
  • Trains new laboratory personnel.
  • Performs other related work as needed.


Minimum Qualifications

Education:

Minimum requirements include a PhD in related field.

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Work Experience:

Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.

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Certifications:

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Preferred Qualifications

Education:

  • Ph.D. in a biochemistry area or related field.

Experience:

  • strong experience in tissue culture (BSL2), protein expression in human cell lines, stable cell line generation, lentivirus, and retrovirus transduction.
  • Experience in engineering human T cells, experience in phage display mutagenesis, and fluorescent microscopy techniques.
  • Experience in mentoring students is important.

Preferred Competencies

  • Hands-on proficiency in primary immune cell isolation, culture, phenotypic and functional characterization of immune cells required.
  • Hands-on experience with in vitro and ex vivo functional assays of primary human T cells, T cell killing assays, cytokine assays required
  • Experience on human signal transduction and protein-protein interaction assays required.

Working Conditions

  • Ability to work independently and as a part of team.
  • Ability to work with animal in the research lab.
  • Ability to train others.

Application Documents

  • Resume (required)
  • Three references (required)


When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Resume/CV of the application.


Job Family

Research


Role Impact

Individual Contributor


FLSA Status

Exempt


Pay Frequency

Monthly


Scheduled Weekly Hours

40


Benefits Eligible

Yes


Drug Test Required

No


Health Screen Required

No


Motor Vehicle Record Inquiry Required

No


Posting Statement

The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national or ethnic origin, age, status as an individual with a disability, protected veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.

Staff Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.

We seek a diverse pool of applicants who wish to join an academic community that places the highest value on rigorous inquiry and encourages a diversity of perspectives, experiences, groups of individuals, and ideas to inform and stimulate intellectual challenge, engagement, and exchange.

All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.

The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at: http://securityreport.uchicago.edu. Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.

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