Postdoctoral Research Associate Position Open in the Weikai Li Lab (Department of Biochemistry and Molecular Biophysics).
A postdoc position is immediately available for a highly motivated individual to study membrane enzymes, transporters and adhesion molecules that are important therapeutic targets in hematology and cardiovascular biology. To support the study, Dr. Weikai Li’s lab at Washington University in St. Louis has developed multidisciplinary approaches that combine novel structural biology and mass spectrometry methods with biochemistry and cell biology. Recent publications of the lab include those in Science, Science Adv., EMBO J and NSMB. The lab is well funded by five grants from NIH and other foundations, which can support the entire duration of postdoctoral study. More information of the lab can be found at https://weikailab.wustl.edu .
Current projects in the lab include:
- Cryo-EM and crystal structures of several membrane proteins and complexes important in hematology and cardiovascular biology.
- Development of Cryo-EM methods to readily solve structures of most membrane proteins.
- The degradation pathway of ferroportin (the only iron exporter) and its protective role of cardiomyocytes.
- How cellular interactions of tetraspanin CD53 regulate B cell trafficking.
- The cellular organization of tight junction formation mediated by claudins and associated molecules.
Furthermore, the lab culture encourages free exploration, and the fellow is welcome to develop their own research projects and strategies that are of mutual interest. High degrees of motivation and independency are greatly appreciated. On the other hand, the PI is always available to provide advice.
The postdoc candidate should have strong background and publication record in either structural biology, biochemistry or cell biology. Based on previous experiences, the postdoc may choose to work on cryo-EM and crystal structures of membrane proteins, study their biochemistry and cell biology, or combine with mass spectrometry to elucidate their native states and interactions.
In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs .
PRIMARY DUTIES AND RESPONSIBILITIES:
Train under the supervision of a faculty mentor, including (but not limited to): Manage their own project, which should lead to a first author publication. Develop expertise in cryo-EM, membrane protein purification and crystallization. Develop proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature. Present scientific work both inside and outside the University with excellent oral communication skills. Assist with grant preparation and reporting. Prepare and submit papers on research with excellent writing skills. Design research experiments. Evaluate research findings and reports results. Maintain conscientious discharge of their research responsibilities. Maintain conformity with ethical standards in research. Maintain compliance with good laboratory practice, including the maintenance of adequate research records and efforts to maintain general lab health and growth. Engage in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications. Maintain collegial conduct towards co-trainees, staff members and members of the research group. Adhere to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.