At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

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• Initiates, directs and executes pre-clinical scientific research and/or development strategies in research and/or development

• Design and build innovative in vitro & in vivo approaches to screening drug candidates, both internally and through CRO and academic collaborations

• Utilize subject-matter expertise and past-experience to influence the direction of research projects including new target due diligence

• Work closely with translational biology / biomarker teams

• Maintains broad knowledge of state-of-the-art principles and theories

• Makes major contributions to scientific literature and conferences

• May act as spokesperson on corporate research and development and advise top management

• May participate in development of patent applications

• Interfaces with various departments and serves as internal consultant

• Biologics specific work will include work on Gene Therapy/mAb/peptide projects from inception to IND-enabling studies. Works with internal colleagues and external collaborators across all disciplines of R&D to select targets and develop Biologics products. Works with the R&D team to design and implement a robust strategy for the growth of the Biologics drug development. Design in vitro and in vivo strategies for development of Biologics and conduct and/or manage in vitro and in vivo studies to measure potency and efficacy. Monitors the latest developments in the Biologics Therapy space for opportunities to in-license or acquire technologies. Prepares detailed data reports and present results to peers, colleagues, and collaborators. Presents data as appropriate at scientific meetings at the National and International level

• Ability to deliver drug substance to clinical trials and beyond through the transition period from research to development

• Other duties as assigned

• BS/BA degree and 8+ years of experience in the biotech/pharmaceutical industry identifying and developing cell-based disease models capable of miniaturization for drug screening purposes. Experience with primary neurons and iPSC-derived neurons, and their use in assay development, is beneficial. Experience assessing the pharmacological efficacy and MOA of small molecule drug candidates OR

• Master's degree in biology, life sciences or related discipline and 6+ years of experience in the biotech/pharmaceutical industry identifying and developing cell-based disease models capable of miniaturization for drug screening purposes. Experience with primary neurons and iPSC-derived neurons, and their use in assay development, is beneficial. Experience assessing the pharmacological efficacy and MOA of small molecule drug candidates OR

• PhD or equivalent and 4+ years of relevant experience; may include postdoc experience, Gene Therapy positions will require a PhD in Pharmacology, Neuroscience, Endocrinology, Physiology, or closely related discipline

• Gene Therapy position will require a minimum of 4 years of experience in the biopharmaceutical industry

• Advanced tissue culture techniques, protein expression and purification and analysis

• Working knowledge of NGS (next generation sequencing) technologies, their implementation, and data analysis & relevant statistical tests

• Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (ASO, siRNA, miRNA, AAV transduction)

• Tissue handling techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH

• Knowledge of protein structure function relationships

• Ability to utilize bioinformatics software for protein and gene analyses

• GTX - Tissue handling techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH

• MAbs/bi specifics - understanding of antibody protein structure & function, ability to apply protein engineering principles to mAb drug design. Practical experience with affinity determination methods, and execution of antibody optimization campaigns using directed evolution screening platforms. Knowledge of immunogenicity assays, and state-of-the-art antibody technologies

• Proven strong track record in advanced experimental technologies and their utilization in the drug discovery process

• Expertise with identifying and developing cell-based disease models capable of miniaturization for drug screening purposes

• Experience with primary neurons and iPSC-derived neurons, and their use in assay development, is beneficial

• Experience assessing the pharmacological efficacy and MOA of drug candidates

• Excellent critical analysis skills

• Assimilates data and research findings outside of Neurocrine for application to new scientific projects

• Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas

• May develop an understanding of other areas and related dependencies

• Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools

• Ability to work as part of and lead multiple teams

• Exhibits leadership skill and ability, typically leads lower levels and/or indirect teams

• Excellent computer skills

• Excellent communications, problem-solving, analytical thinking skills

• Sees broader picture, impact on multiple programs, teams and/or departments

• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency

• Excellent project management skills

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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