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Research Scientist - Pediatrics
Case Western Reserve University in Cleveland, Ohio
 
 
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Date Posted 03/04/2021
Category
Admin-Laboratory and Research
Employment Type
Application Deadline Open until filled
 
 
 
 
 

Date: February 2021

Title: Research Scientist

Department: Pediatrics          

School: Medicine         

Location: BRB 8th floor

Supervisor Name and Title:  Cynthia Bearer, MD, PhD, Professor

POSITION OBJECTIVE

A new developmental neurotoxicity research program in the Department of Pediatrics at the Case Western Research University School of Medicine is seeking a Research Scientist (RS) to plan and execute 6+ projects in collaboration with other laboratory members and faculty members from CWRU and other academic institutions.  As a collaborator, the RS will develop molecular and cellular biological assays to measure dysfunction of lipid rafts.  These assays will include use of complex instrumentation including confocal microscopy, behavioral testing, lipidomics, proteomics and metabolomics related to lipid rafts in vitro and in vivo.

ESSENTIAL FUNCTIONS

The responsibilities of this position include:

  • The Research Scientist (RS) will participate in the development of assays measuring the composition and function of lipid rafts including cell signaling, neurite outgrowth, nakanori staining, live cell imaging, and identification and isolation of lipid rafts.
  • Translate methods into clinical applications and will work with clinicians to address technical questions.
  • Independently write and apply for grant funding as the PI for projects related to the research focus of the lab. As a PI, the RS will collaborate with the PI/Supervisor as a research team, conducting their own research project within the area of interest of the lab and as agreed on with the PI.
  • Collaborate with faculty members from the division of neonatology, the department of Pediatrics, CWRU and other academic institutions.
  • Prepare manuscripts and contribute data for the PI’s grant proposals. 
  • Participate in studies related to NIH grant (Project PI Bearer):  Determine lipidome, proteome and lipid oxidation species of lipid rafts from animals undergoing hypoxic-ischemic brain injury, hyperbilirubinemia, excipient/ethanol exposure and the effect of choline supplementation on these effects. Determine behavioral effects of these exposures on rat/mouse pups.
  • Participate in studies to prepare for NIH grant applications including R01 on impact of hyperbilirubinemia on lipid rafts; R01 on effect of excipients on lipid rafts, and R01 on mechanism of choline’s neuroprotection.
  • Oversee research activities of other members of the lab including research assistants and trainees in the laboratory, and propose research activities of interest to fellows. Help troubleshoot problems with their experiments and be a constant resource for more junior members of the lab. Assume weekend duties including feeding of the animals, mating for appropriate gestation age of pups, and experiments requiring weekend activities.
  • NONESSENTIAL FUNCTIONS

  • Perform other duties as assigned.
  • CONTACTS:  Department: PI (Cynthia Bearer) (regular), collaborators (moderate), Faculty, research staff, clinical staff, administrative staff

    University: Other departments as needed

    External: University Hospital physicians, Industrial Partner scientists, engineers, and management

    Students: Undergraduate, graduate students, postdoctoral fellows and clinical research fellows

    SUPERVISORY RESPONSIBILITY

    This RS will supervise research assistants, work study students, volunteers, graduate students, medical students, residents and fellows in conducting molecular biologic and biochemical assays, lipid raft research, confocal image acquisition and data analysis for a variety of projects using a variety of techniques. The RS will oversee all aspects of the laboratory (Lab manager).

    QUALIFICATIONS

    Experience: 10 or more years of experience in lipid raft analysis.

    Education/Licensing: Ph.D.

    REQUIRED SKILLS

  • Proficiency in Cell Culture: primary cells, stem cells
  • Proficiency in Molecular Biology: DNA/RNA isolation, real-time PCR, QPCR, molecular cloning
  • Proficiency in Immunoassay: ELISA, flow cytometry analysis, Western blot, Southern blot, dot blot, protein purification and hybridizations, immunoprecipitation, immunofluorescence staining, fluorescent light and confocal microscopy
  • Proficiency in Histology: Paraffin/Cryostat sectioning and staining,
  • Proficiency in Microbiology: Aseptic Testing, plating, tubing, and membrane filtration, cell transfection
  • Proficiency in isolation of lipid rafts using sucrose density gradients and ultracentrifugation:
  • Proficiency in Animal management: rats and mice husbandry/breeding, genotyping and managing specific colonies, gavages/IV/IP injection, perfusion, tissue collection and dissection, animal behavioral studies
  • Proficiency in MS office (Excel, Word, PowerPoint), Adobe Photoshop, Image J
  • Others: Write IACUC animal protocols, update lab protocols, assistance with the design and conduct of research projects, order supplies, supervise research assistants, medical students, master /PhD students and medical fellows
  • Strong organization skills; ability to multi-task, prioritize and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through.  
  • Excellent customer service skills; ability to maintain effective working relationships and address the potential and current needs of customers.
  • Effective management skills; ability to lead, train, work with, and elicit cooperation from team members and staff.
  • Ability to work effectively independently and collaboratively within a team.  Must be highly motivated, responsible, dependable and a self-starter.
  • Effective problem-solving skills; must demonstrate excellent analytical skills, sound judgment and good decision-making. 
  • Must demonstrate flexibility and ability to work under pressure; must be able and willing to work in a fast-paced, changing environment, and conform to shifting priorities, demands and timeline. 
  • Willingness and ability to rely on and follow instructions and pre-established guidelines to perform the functions of the job.
  • Ability to operate laboratory equipment
  • Must demonstrate eagerness to learn new techniques, procedures, processes, and computer programs as needed.
  • Must speak and write English proficiently
  • WORKING CONDITIONS

    The work will be performed in a translational research program which includes office and laboratory environments.  Some of the work will occur on the weekends. Occasional travel to visit the industrial partners and for attending scientific conferences.

    Please send all resumes to Cynthia Bearer at cfb3@case.edu


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