Posted: 21-Oct-23

Location: Portland, Oregon

Type: Full-time

Salary: Open

Categories:

Internal Number: 26241

OHSU Casey Eye Institute is a premier academic medical center providing eye care for adults and children in the Pacific Northwest and beyond. We treat eye conditions from the most straightforward to the most complex, and offer expert care in all ophthalmology specialties. OHSU Casey Eye Institute has one of the top ophthalmic research programs in the country. Our scientists and clinicians have worked together to perform research studies that have revolutionized the practice of ophthalmology, and we continue to explore, innovate, and find new treatments for eye disease.

OHSU Casey Eye Institute's faculty are responsible for many of the most recent advances in ophthalmology, which have revolutionized the diagnosis and treatment of many ophthalmic conditions. Advances in optical coherence tomography, ophthalmic informatics, corneal refractive, retina and pediatric eye care have been pioneered at Casey.

This is a postdoctoral research position in the Chirco Lab at the Casey Eye Institute. The researcher will work on a funded project, which is focused on conducting translational research using human iPSCs and retinal organoids. This work will focus on better understanding and treating Bardet-Biedl Syndrome, a rare, syndromic form of retinitis pigmentosa. Duties will include performing tissue culture, bench research with the samples grown in the lab, testing and optimizing gene editing tools for therapeutic development, and manuscript writing. The applicant will be expected to manage and execute all experiments associated with their research projects. The applicant must have a Ph.D. or equivalent degree in biological sciences, preferably molecular or developmental biology. Diversity is highly valued at OHSU and within the Chirco Lab. Applicants from underrepresented backgrounds are highly encouraged to apply.

Generate and grow iPSCs and human retinal organoids, evaluate therapeutics in the generated iPSCs and retinal organoids, characterize retinal disease features and gain a mechanistic understanding for the development of BBS7-mediated retinal disease.

Develop a rhesus macaque retinal organoid model system as a precursor for testing therapies in nonhuman primate models, including newly developed therapeutics and/or cell transplantation.

PhD in molecular biology or related field.

Cell culture experience, molecular and/or developmental biology background, benchwork skills including PCR, IHC, Western blotting, etc.

Applicant must be motivated and enjoy working independently as well as in a collaborative environment. Excellent communication skills, ability to manage competing priorities, and ability to meet deadlines is also required.

PhD thesis includes research on retinal degeneration is preferred.

Stem cell culturing experience, familiarity with the retina, basic understanding of genetics and CRISPR is preferred.

All are welcome
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.