Details

Posted: 07-Oct-23

Location: Washington, D.C.

Type: Full-time

Salary: Open

Categories:

Academic/Faculty
Biological/Biomedical Sciences

Internal Number: 4667269

Postdoc - Laboratory for Brain Injury and Dementia
Georgetown University: Medical Center: School of Medicine: Neuroscience
Location: Medical Center
Open Date: Oct 05, 2023
Deadline:
Description
The Laboratory for Brain Injury and Dementia in the Department of Neuroscience at Georgetown University Medical Center is searching for a postdoctoral fellow to work on the neuroscience of memory formation and memory loss following traumatic brain injury (TBI). TBI and repetitive head impact (HI) are a leading cause of cognitive impairment in humans, especially in young adults and adolescents. The Laboratory for Brain Injury and Dementia uses in vivo brain trauma models to understand how TBI impacts normal brain function, and why it can result in the activation of pathways involved in chronic neurodegenerative diseases such as Alzheimer's disease or Chronic Traumatic Encephalopathy. Our overarching goal is to understand how and why severe TBI or repeated HI results in the development of cognitive impairment, behavioral abnormalities, and dementia. We use advanced techniques including RNA sequencing to unlock how TBI alters our transcriptome, proteomics to discover new protein targets to treat TBI, EEG to visualize how TBI alters brain waves and sleep patterns, and electrophysiology to understand how TBI changes our synapses and communication between neurons.
For this position, the successful candidate will lead a preclinical research project focusing on how memory cells in the hippocampus and other brain regions are impacted by TBI and HI, and if we can reverse memory loss and cognitive impairment and return normal brain function. The research is focused on the memory engram, and how it is affected after TBI. The postdoctoral fellow will be responsible for designing, planning, conducting, analyzing, and reporting experimental data resulting from this research project. We are searching for a postdoctoral fellow with experience in mouse surgery, basic molecular and cellular biology techniques, mouse behavior, electrophysiology, brain stimulation, or transcriptomic analysis.
Responsibilities:

• Conducts experiments in mouse and rat models of TBI and HI using cutting edge techniques for molecular pathway analyses of cellular responses to acute injury and during neurodegeneration, and the effects of candidate treatments to reverse memory loss and restore normal brain function.
• Performs highly skilled and specialized surgeries involving stereotaxic brain injection, stereotaxic brain implants, optogenetic stimulation, tissue clearing, and synapse reconstruction.
• Formulates experimental hypotheses, designs, and executes experimental protocols.
• Makes scientific observations, maintains detailed workbooks/documentation, and ensures documentation fulfills generally accepted professional/industry standards. Analyzes and interprets experimental data, including statistical analyses.
• Coordinates and contributes to new grant and funding applications.
• Trains and supervises laboratory technicians, graduate students, and undergraduate students, as needed.
• Prepares written reports and manuscripts for submission to scientific journals.
• Participate in the management of the lab, including conforming to lab safety standards, ordering supplies, and submitting required safety and budget paperwork. Attendance and participation in required training is mandatory.

Work Environment

• This position will take place primarily in a laboratory setting.
• Depending upon specific study requirements, evening, holiday, or weekend work may occasionally be required.
• The Laboratory for Brain Injury and Dementia is committed to welcoming and supporting people from all cultures and identities. TBI does not discriminate against color, creed, sex, sexual orientation, or gender and we require individuals to bring their unique perspectives to TBI research.
• This position uses the NIH-NINDS postdoctoral salary scale, which varies depending on experience.

Qualifications
Required Knowledge, Skills and Abilities

• Laboratory and animal research experience are required.
• Ability to work independently and supervise others is a requirement.
• Excellent communication skills (both verbal and written) are required.
• Knowledge of complex scientific procedures and techniques is required.
• Ability to troubleshoot technical procedures is required.
• Experience with analyses of molecular pathways and cellular responses is required.
• Knowledge of how to use and manipulate the memory engram in mice is strongly preferred.
• Experience with brain clearing, brain stimulation (TMS or tDCS), patch clamp electrophysiology, or transcriptomic analysis are beneficial.

Education and Experience

• A doctorate or equivalent degree in Neuroscience (or related discipline) is required for this position.
• Minimum of 2-5 years of relevant experience is required for this position.

Application Instructions
Please submit
1) a CV listing your education, skills, abilities, mentoring history, grant applications (funded and unfunded), and publications.
2) a cover letter
For more information and to apply, visit https://apply.interfolio.com/133732
Georgetown University is an Equal Opportunity/Affirmative Action Employer fully dedicated to achieving a diverse faculty and staff. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, national origin, age, sex (including pregnancy, gender identity and expression, and sexual orientation), disability status, protected veteran status, or any other characteristic protected by law .
If you are a qualified individual with a disability and need a reasonable accommodation for any part of the application and hiring process, please click here for more information, or contact the Office of Institutional Diversity, Equity & Affirmative Action (IDEAA) at (202) 687-4798.
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