We are immediately seeking a postdoctoral fellow who is a recent PhD or MD/PhD graduate in biomedical science and cancer research. The ideal candidate will possess a track record of successful study and have documented publications in internationally peer-reviewed scientific journals. Final selection will be based on the expertise and motivation of the candidate.

The main goal of this position is in studying the underlying mechanisms of polyploid giant cancer cells in therapeutic resistance. Polyploid giant cancer cells (PGCCs) can give rise to therapy-resistant cells in various types of solid tumors, but their association with olaparib-resistance in high-grade serous carcinomas (HGSCs) - the most common type of ovarian cancer - is unknown. The successful candidate will join our lab in contributing to the development of preclinical projects that include multiple experimental approaches. This role will also include analyzing and interpreting data, managing data to communicate the scientific findings at informal and formal meetings, and preparing abstracts and manuscripts for presentation and publication in peer-review journals. As such, the ideal candidate must have demonstrated ability to conduct independent scientific investigations.

The University of Texas M.D. Anderson Cancer is #1 ranked cancer center in the US and offers rich environment for research and professional development. If interested, please send a cover letter, CV, name and contact information of at least three references to: Jinsong Liu, MD/PhD, Professor, Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4095. E-mail: jliu@mdanderson.org. Tel/Fax: (713) 745-1102/(713) 563-1848.

LEARNING OBJECTIVES
We are interested in studying the underlying mechanisms of polyploid giant cancer cells in therapeutic resistance. Our group found that polyploid giant cancer cells (PGCCs), which have been generally considered non-viable due to their inability to execute mitosis, can grow and divide via amitosis. These giant cancer cells may function as the most primitive cancer stem cells via dedifferentiation into blastomere-like stem cells (Zhang et al, Oncogene, 33(1):116-28, 2014; Niu et al, Oncogenesis 5(12):e281, 2016; Niu et al, Oncogene 36(34):4887-4900, 2017). We have recently provided live cell images of PGCCs and provided first experimental evidence that targeting PGCCs can improve the therapeutic efficiency and combat the resistance( Li et al, Oncogene, 2023; Zhang et al, Sci Advances, 2023).

ELIGIBILITY REQUIREMENTS
The candidate must have a track record of successful Ph.D. study and have documented publications in internationally peer-reviewed scientific journals and great scientific English language skill. In addition to superb lab skills, the candidate must have demonstrated ability to conduct independent scientific investigations. A strong background in cell biology, cancer biology, molecular biology, and pathology is required. The position will be open until filled.

ADDITIONAL APPLICATION INFORMATION
The University of Texas M.D. Anderson Cancer is #1 ranked cancer center in the US and offers rich environment for research and professional development. If interested, please send a cover letter, CV, name and contact information of at least three references to: Jinsong Liu, MD/PhD, Professor, Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4095. E-mail: jliu@mdanderson.org. Tel/Fax: (713) 745-1102/(713) 563-1848

POSITION INFORMATION
MD Anderson follows the NIH stipend levels as outlined by the Kirchstein - NRSA . This full-time trainee position will provide a salary between $56,484 to $68,604, dependent upon the years of postgraduate experience.

MD Anderson offers compensated trainees:
- Paid medical benefits (zero premium) starting on first day for trainees who work 30 or more hours per week
- Group Dental, Vision, Life, AD&D and Disability coverage
- Paid Education Vacation and Sick Leave
- Paid institutional holidays, wellness leave, childcare leave and other paid leave programs
- Teachers Retirement System defined-benefit pension plan and two voluntary retirement plans
- Employer paid life, AD&D and an illness-related reduced salary pay program
- Health Savings Account and Dependent Care Reimbursement flexible spending accounts
- Fertility benefits
- State of Texas longevity pay
- Extensive wellness, fitness, employee health programs and employee resource groups