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Postdoctoral Research Fellow Positions in RNA Biochemistry

Kathy Liu Lab

Job Description


Postdoctoral Research Fellow Positions in RNA Biochemistry

at the University of Pennsylvania

Two fully funded postdoctoral research fellow positions are available in Kathy F. Liu Lab in the Department of Biochemistry and Biophysics and the RNA Innovation Center at the University of Pennsylvania (Penn).

The Liu Lab utilizes modern enzymology, biochemistry, biophysics, cell biology, and bioinformatics to investigate

  • the functions of RNA-modifying enzymes in cancer,
  • how sex chromosome-encoded proteins function in sex bias of human disease.
  • The cutting-edge and multidisciplinary research direction provides postdocs with the best training and opportunities for their future independent career.

    Lab website: https://www.med.upenn.edu/kathyliulab/

    Lab Twitter: https://twitter.com/LiuFange

    The Liu Lab at Penn has published multiple high-profile papers in PNAS, Molecular Cell, JBC, and Genes & Development since its inception in 2018. The Lab has also obtained multiple R01-size grants from NIH and funding from the American Cancer Society and Damon Runyon Cancer Foundation to support their cutting-edge research in RNA enzymology and epitranscriptomics.

    The ideal candidates are expected to have a strong background in either of the following areas, including biochemistry, structural biology, bioinformatics, RNA biology, and molecular biology. Extensive experience in one or more areas, including molecular cloning, protein purifications, mass spectrometry, RNA biochemistry, structural biology, and deep sequencing technologies, is highly desirable.

    As a private Ivy League research university, Penn offers a world-class environment for RNA biology and gene transcription regulation research. In an interdisciplinary collaborative research group, the successful candidate(s) will have access to state-of-the-art equipment and study modern RNA cellular enzymology and sex differences in gene regulation at the molecular level. Philadelphia is the sixth-most populous city in the United States, notable for its rich history and fun. A broad range of career advancement and specialized training opportunities is available on campus throughout the year.

    REQUIREMENT

    • Ph.D. in Chemistry, Biochemistry, Biophysics, Biology, or closed related fields.
    • Expertise and lab experience in at least one of the following areas:
  • molecular cloning
  • Protein biochemistry, including protein expression and isolation
  • Encymology
  • mammalian cell culture (using induced pluripotent stem cells is a plus)
  • DNA/RNA biology
  • RNA extraction and RNA library preparation (RNA-seq, CLIP-seq, MeRIP, ribosome profiling)
  • Bioinformatic analysis of high-throughput sequencing data
  • advanced mass spectrometry technologies (Triple Quadrupole Mass Spec, Q-TOF, Orbitrap, TOF/TOF)
  • X-ray macromolecular crystallography
  • Cryo-EM
    • Demonstrated proficiency in data acquisition, analysis, and manuscript preparation.

    HOW TO APPLY

    Please direct inquiries, CV, and contact information of three referencesvia email to Dr. Kathy F. Liu at liufg@pennmedicine.upenn.edu.


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