Details

Posted: 15-Sep-23

Location: Chapel Hill, North Carolina

Salary: Open

Internal Number: 265496

Vacancy ID: PDS003967

Position Summary/Description:

The UNC HIV Cure Center in the Institute of Global Health and Infectious Disease and School of Medicine at the University of North Carolina at Chapel Hill in collaboration with basic science departments in the School of Medicine and across the University of North Carolina at Chapel Hill invites applications for a Postdoctoral Research Fellow. The UNC HIV Cure Center is focused on the discovery, development, and implementation of new treatments to allow durable treatment-free remission of HIV infection (cure). The HIV Cure Center is supported by University and federal funds, and by a public-partnership between the University of North Carolina at Chapel Hill and Glaxo SmithKline. The Center seeks to co-mingle academic and industry approaches, redefining research and seeking the breakthroughs needed to tackle this extraordinarily challenging global health issue.
We are seeking a highly motivated, independent, and dynamic postdoctoral research fellow to undertake research at the UNC HIV Cure Center, specifically in a project seeking to understand HIV persistence and eradication strategies for the cure of HIV. The UNC HIV Cure Center is a multi-disciplinary research center with various current translational studies. Our laboratory is interested in understanding of HIV latency and persistent HIV infection-associated complications. We seek to discover new anti-HIV latency therapeutic targets that will ultimately lead to the eradication of HIV infection, including kick and kill, direct killing, and deep latency. A variety of HIV latency models will be used in this study, including in vitro and ex vivo cellular models of latency, and ART-suppressed rhesus macaque model of latency. Tissues (CNS and periphery) isolated from people with HIV on ART, SIV/rhesus macaques and HIV/hu-mice are extensively studied.

Education and Experience:

The ideal candidate will have experience and interest in cellular and/or animal models of SIV/HIV infection or other viral infection models with expertise in flow cytometry, tissue culture, and cellular immunology to facilitate the translational research at the clinical/basic science interface. He/she should also be proficient in microscopy techniques and immunostaining. Preference will be given to candidates with extensive experience in tissue processing, primary cell culture, flow cytometry and molecular biology/biochemistry techniques such as co-immunoprecipitation, chromatin immunoprecipitation, qPCR/RT-qPCR, and western blot analysis. Single-cell omics (scRNA-seq, ATAC-seq, etc.) training in neurobiology will be a plus. Opportunities will exist for gaining teaching experience with graduate and clinical research fellows. Candidates should also have strong laboratory and analytical skills as demonstrated by a strong track record of relevant 1st author publications in well-respected journals. Outstanding communication skills in English are essential for this position.
He/she should also be proficient in microscopy techniques and tissue immunostaining.
Preference will be given to candidates with extensive experiences in tissue processing, primary cell culture, flow cytometry (including CyTOF) and molecular biology/biochemistry techniques such as co-immunoprecipitation, chromatin immunoprecipitation, DNA and RNA analysis by qPCR, and western blot analysis.
Opportunities will exist for gaining teaching experience with graduate and clinical research fellows.
Candidates should also have strong laboratory and analytical skills as demonstrated by a strong track record of relevant publications in well-respected journals.

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Carolina rates among the nation’s great institutions of higher education, set on an historic and beautiful campus that celebrates all four seasons. Carolina’s students, faculty and staff come here from around the world, bringing varied cultural, racial and ethnic heritages that help make UNC-Chapel Hill a thriving intellectual center. We’re repeatedly ranked the nation’s best value in higher education for students seeking to earn a college degree – the University has garnered the top spot each time since the ranking’s launch in 1998.Whether you’ve just started your career, are new to academia or are a seasoned professional with assorted campus experiences to draw on, we hope you will find a great place at Carolina.
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