The Maj-Linda Selenica’s laboratory in the Sanders-Brown Center of Aging, Departments of Biochemistry at University of Kentucky is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of our efforts to unravel mechanisms contributing to the TDP-43 pathology of limbic-predominant age-related TDP-43 encephalopathy (LATE) and other Alzheimer’s Disease Related Dementias (ADRD). Core areas of focus will be understanding the role of citrullination and other PTMs in the TDP-43 protein structure, biology, and pathology  into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand the clinical outcomes of TDP-43 pathogenesis in LATE and ADRD. Our lab concentrates on identifying the role of citrullination in recombinant TDP-43 liquid-liquid phase separation and aggregation kinetics (ThT, TEM, FRAP) and dissecting the molecular, cellular, and tissue-level mechanisms by which this PTM and the associated enzymes (e.g., PADs) modulate disease risk, with a major focus on cell-specific role on the regional milieu and disease pathology. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, immunologists, biostatisticians, neuroscientists, and neuropathologist at the Sanders-Brown Center on Aging as one of the leading centers in the country for ADRD and LATE research and clinical interventions.

Qualifications and Skills

• Ph.D. in Biology, Neuroscience, or related field with deep expertise in molecular and cellular biology techniques Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred) – or – Strong research experience in high-throughput technologies single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred) – or – Strong research experience in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9) screens (preferred) Strong research experience in establish, modify, and optimize techniques related to the areas of neuroscience, inflammation, and disordered proteins. Expertise in high throughput imaging techniques including but not limited to confocal, electron microscopy, FRAP, 2P imaging. Strong research experience in small animal surgery, AAV methods etc., is highly preferred. Knowledge of experimental design Statistical and quantitative analysis skills Basic bioinformatics skills (preferred) Self-motivated and highly dedicated Effective organizational and prioritization skills Strong writing skills evident in published work and efficient grantsmanship skills Effective oral, written, and interpersonal communication skills Ability to work both independently as well as collaboratively in a multidisciplinary environment.

 Strength Through Diversity

The Sanders-Brown Center on Aging and Selenica Laboratory strongly believes that diversity and inclusion is a driver for excellence. We share a common devotion to delivering exceptional patient care. Yet we’re as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Sanders- Brown Center on Aging unrivaled record of achievement, education, and advancement as we revolutionize healthcare delivery together.

We work hard to recruit and retain the best people, and to create a welcoming, nurturing work environment where you have the opportunity and support to develop professionally. We share the belief that all employees, regardless of job title or expertise, have an impact on quality patient care.

 Explore more about this opportunity and how you can help us write a new chapter in our story!

 To apply, please submit an online application to requisition number DU11167at https://ukjobs.uky.edu, or follow this link https://ukjobs.uky.edu/postings/484186