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Job Title:
Post Doctoral Scholar

Department:
Pharmacy | Pharmaceutics and Pharmacology

A postdoctoral scholar position is available to study the relative contribution and composition of extracellular vesicles from normal and cancerous tissues. This exciting project will contribute to define the potential of extracellular vesicles as cancer biomarkers. The postdoctoral scholar will have the unique opportunity to work in a highly interdisciplinary environment from basic to translational cancer research that creates the potential for bench-to-bedside discoveries.

The postdoctoral scholar will develop new laboratory methods, including live cell microscopy, gene editing, and animal models to achieve characterization and quantification of extracellular vesicle release in in vitro and in in vivo models of normal physiology and disease status. The study will permit the identification of novel biomarkers and to examine their role in cancer development.

Qualifications:

The successful candidate will have the following:

• Candidates must hold a Ph.D. or M.D awarded within the last three years.

• Preference will be given to applicants that have demonstrated expertise with publication records in at least three of the following areas:

1. Cell Biology: cell culture, gene editing, flow cytometry

2. Small Animal studies: familiar with mouse models

3. Molecular biology: gene manipulation

4. Extracellular Vesicle biology: EV purification, basic characterization techniques

5. Cell imaging: fixed and live cell microscopy using confocal, TIRF and/or light sheet microscopy

6. Data Analysis: able to analyze large data set using MATLAB, R and/or Python.

• Minimum of a first author publication

• Strong written and communication skills

• High level of motivation, enthusiasm, and the ability to work independently and in teams to pursue high quality research

Laboratory: The research will be performed in the laboratory of Pharmacology of Membrane Traffic, in the College of Pharmacy, Division of Pharmaceutic and Pharmacology led by Dr. Cocucci Emanuele, at The Ohio State University. Dr. Cocucci is a renewed expert in the fields of membrane trafficking and extracellular vesicle biology who contributed more than 30 papers in high impact journals including Cell, Nature Cell Biology, Plos Biology, PNAS, and Trends in Cell Biology . In the laboratory five-dimension quantitative cell imaging approaches have been established, based on the revolutionary lattice light sheet microscope. We applied these techniques to elucidate the role of the adaptor protein CALM in the formation of clathrin coated vesicles upon membrane tension increase (a) and to elucidate the exchange of extracellular vesicles in real time in living cells (b,c). These techniques are also the foundation for the Extracellular Vesicle (EV) intensity calibration that we will routinely use in this research project.

The laboratory is also affiliated with the Wexner Medical Center, and the candidate will have access to cutting edge facilities and optimal training to successfully conduit research and be prepared for the next career steps. The Principal Investigator will provide a collaborative and inclusive research environment and encourage the preparation of manuscripts, fellowship applications, and data presentations. 

a. Willy NM, Colombo F, Huber S, Smith AC, Norton EG, Kural C, and Cocucci E . CALM supports clathrin-coated vesicle completion upon membrane tension increase. PNAS, 2021; 118 (25): e2010438118. PMID: 34155137.

b. Elgamal S, Colombo F, Cottini F, Byrd JC and Cocucci E . Imaging intercellular interaction and extracellular vesicle exchange in a co-culture model of chronic lymphocytic leukemia and stromal cells by lattice light sheet fluorescence microscopy. Methods in Enzymology , 2020. PMID: 33565979

c. Federico Colombo, Erienne Grace Norton, Cocucci E . (2022) Extracellular Vesicle exchange is favored by cell proximity. bioRxiv . 2022.05.10.491399 doi: https://doi.org/10.1101/2022.05.10.491399

Additional Information:

Application instructions: Please include a cover letter describing your past research accomplishments and future research interests, curriculum vitae, and contact information of three references as part of your application. Applications will be accepted until the position will be filled.

The Ohio State University’s Shared Values  include Excellence and Impact, Diversity and Innovation, Inclusion and Equity, Care and Compassion, and Integrity and Respect. Our university community welcomes differences, encourages open-minded exploration and courageous thinking, and upholds freedom of expression. We define diversity broadly and value multiple dimensions of diversity including, but not limited to demographic, religion, country of origin, perspective, ability status, and background. 

Ohio State prides itself on welcoming a wide range of viewpoints and providing opportunities for all to deepen and develop their intellectual curiosities. As a land-grant university, we recognize and understand that a diverse faculty, staff, and student body in which all may engage in open dialogue, be exposed to new ideas and perspectives, belong, and feel valued and included is essential to our efforts in meeting our mission of academic excellence and public service.

Location:
Biomedical Research Tower (0112)

Position Type:
Term (Fixed Term)

Scheduled Hours:
40

Shift:
First Shift

Final candidates are subject to successful completion of a background check.  A drug screen or physical may be required during the post offer process.

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