City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines , as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope's growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilities in Atlanta, Chicago and Phoenix. City of Hope's affiliated group of organizations includes Translational Genomics Research Institute and AccessHope TM . For more information about City of Hope, follow us on Facebook , Twitter , YouTube , Instagram and LinkedIn .

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We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

The Beckman Research Institute of City of Hope is looking for a talented, highly motivated, and hard-working Postdoctoral Fellow.The Post-Doc will be assigned to projects addressing the rising cases of AIDS-defining cancers (ADCs) and Non-AIDS defining cancers (NADCs), specifically cervical, Head and Neck Squamous cell carcinoma (HNSCC) and Anal squamous cell carcinoma (ASCC). The project will involve designing novel gene therapy approaches to specifically address this unique set of cancers in people living with HIV (PWH). The Post-Doc will be required to develop cell culture assays to study the anti-cancer effects of targeted gene therapies, and then transition the therapies into nanoparticle formulations for testing in vivo in mouse xenograft models.

Basic education, experience and skills required for consideration:

· A Ph.D. degree in life or biomedical sciences, or a related discipline is required. The Post-Doc will need to have the required expertise in a wide-range of basic molecular assays such as cell culture, transfections, recombinant DNA cloning, gene expression analysis, luciferase-based assays, qRT-PCR, ELISA, flow cytometry, and western blots.

· In vivo mouse experience is essential. Additional experience with xenograft and Patient-Derived xenograft (PDX) models will be viewed favorably but not required.

· Working with nanoparticles delivery systems (viral or non-viral), and for this project specifically lipid nanoparticle (LNPs) formulations, will be considered favorably but not required.

· Experience with gene editing and DNA modifying systems, like CRISPR/Cas, Zinc finger proteins, TALENs, will be considered favorably, but not essential.

· BSL2+ training and experience with working with infectious Human Immunodeficiency virus (HIV) will be considered favorably, but not essential.

Additional information:

· For more information about Dr. Tristan Scott's lab, please visit here.

· The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

· As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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