About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes, and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity, and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds, and experiences to our work -- and that our teams align with the people we serve to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds, and perspectives; this is reflected in our work and represented in our people.

Position Summary

A Postdoctoral Fellow position is open in the laboratory of Yingfeng Deng in the Department of Diabetes and Cancer Metabolism at the City of Hope Beckman Research Institute. The Deng laboratory studies the homeostasis of uridine and its role in metabolism, which provides a new angle for understanding the pathophysiology of obesity, diabetes, and cancer.

Work in the lab utilizes both genetically engineered mouse models and in vitro systems. A combination of state-of-the-art surgical, genetic, cellular, biochemical, imaging, and metabolic flux approaches is currently used in the lab.

Following up with the new paradigm revealed about uridine metabolism by Drs. Deng and Scherer (Science, 2017), the Deng lab is currently focusing on three areas:

1) the role of uridine in the progression of obesity and diabetes

2) the physiology of uridine in bile and nutrient absorption

3) the regulation of uridine homeostasis by ER stress and its relevance to breast cancer.

We seek an independent and highly motivated candidate interested in studying the molecular, cellular, and metabolic mechanisms leading to obesity, diabetes, and cancer. Preferably with expertise in using mouse models to study metabolic diseases and using single cell sequencing experiment to profiling tissues/organs.

Basic education, experience and skills required for consideration:

· Ph.D. and/or M.D. degree in life or biomedical sciences or a related discipline is required.

· Experience in basic molecular biology skills.

· Experience in animal models and islet biology.

· Experience in mass spectrometry and/or clamp study.

· Excellent written and verbal communication skills.

· Good problem-solving skills, ability to conduct independent research, ability to work effectively in a team

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

· For a complete list of Publications please visit here: https://www.ncbi.nlm.nih.gov/myncbi/1J54E41I5YVku/bibliography/public/

· To Apply, please attach a cover letter describing your past training and research interests, a detailed CV and contact information of three referees

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.