A Postdoctoral Position is immediately available in the new laboratory of Dr. Stanley Adoro within the Experimental Immunology Branch (EIB), CCR, NCI in Bethesda Maryland. Our research aims to understand how blood cell development is deregulated by disruptions to proteome homeostasis, particularly in blood cancers and tissue degeneration. We utilize state-of-the-art tools in genomics, transcriptomics, and proteomics to assess how changes in proteome homeostasis pathways affect normal blood cell development and disease pathogenesis in relevant human samples and animal models. We anticipate that these studies will uncover vulnerabilities in proteostasis pathways that can be exploited to augment hematopoiesis, improve immune cell function, and treat blood cancers.

The research projects. While the contribution of deregulation in genome integrity to blood cancers is well-established, it is less clear how disruptions in proteome homeostasis (or “proteostasis”) and defects in proteostasis pathways influence blood cell differentiation and the emergence of blood cancers. In the current project, we seek to determine how the unfolded protein response pathway modulates the regenerative capacity of normal hematopoietic stem and progenitor cells and the leukemia stem cell activity that drive acute myeloid leukemia (AML) progression. For these studies, the successful applicant will have access to state-of-the-art confocal microscopy, flow cytometry, transcriptomics, proteomics, and genomics resources available at the EIB and NCI/CCR campus in Bethesda and NCI-Frederick.

Training opportunities. Fellows are encouraged to take advantage of multiple in-person and virtual seminars, focused courses (e.g., training in bioinformatics and translational research) and to actively engage in mentoring and participate in a variety of community activities including various NIH Interest Groups in Immunology, Stem Cells, Proteostasis, etc. Training opportunities are also augmented by collaborations with extramural and intramural investigators including investigators in the Experimental Immunology Branch (https://ccr.cancer.gov/experimental-immunology-branch ) who perform research in basic immunology, signal transduction and molecular mechanisms of diseases.

Ph.D. or equivalent in Immunology, Biochemistry, or related disciplines

Send CV and Letter of Application to stanley.adoro@nih.gov

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