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Neuroscience Postdocs: Ephys/multi-omics/gene therapy in Epilepsy, Autism, Dementia using mice/iPSCs

Job Description


Several positions for highly motivated postdoctoral fellows are available in the laboratory of Dr. Yang Yang, College of Pharmacy, Purdue University to study neurodevelopmental (e.g., epilepsy and autism) and neurodegenerative disorders (e.g., dementia).

The projects are funded by multiple 5-year NIH R01s, generous private donors, Disease Foundation (https://www.newswire.com/news/familiescn2a-foundation-announces-inaugural-2-5m-hodgkin-huxley-22030464), and industry. One projects involve the study ofvoltage-gated sodium channel Nav1.2 (SCN2A-related channelopathy), recently discovered as a top gene mutated in neurodevelopmental disorders (e.g., autism and epilepsy). Anotherline of research involves the study of epigenetics, dementia, and aging. Our lab is well funded with state-of-the-art equipment for carrying out cutting-edge research.

We work on bothmouse modelsand human-induced Pluripotent Stem Cells (iPSCs) derived neurons, together with microglia, 3D brain organoids, and chimeric mouse brain with human cells. We use multidisciplinary approaches includinghigh-density in vivo Neuropixels recording, EEG recording, Inscopix Miniscope in vivo Calcium imaging of freely moving mice, patch-clamp electrophysiology/Patch-Seq, gene therapy (e.g., CRISPR prime editing, base editing, antisense oligonucleotides/ASO), optogenetics andchemogenetics (DREADD), cultured cells, brain slice patch-clamp recordings, single-cell RNA-sequencing, as well as a variety of imaging technologies. Initial results of our studies were recently published in Cell Reports (https://doi.org/10.1016/j.celrep.2021.109495), the Journal of Neuroscience (https://doi.org/10.1523/JNEUROSCI.0564-21.2021), Neurobiology of Disease (https://doi.org/10.1016/j.nbd.2022.105690) among others.

The successful applicant should have completed a PhD or MD in biology, neuroscience, pharmacology, or a related field. While ideal candidates should have expertise in one of the following areas, we also appreciate candidates in other fields who are committed to learning new skills and keen to bring their unique expertise to study neurological diseases in a collaborative environment. Prior trainees competed successfully for national fellowships and secured desirable academia or industry positions. Ample resources and training will be provided for the trainees to grow professionally in academia and path to biotech/pharmaceutical companies.

Areas of interest:

1) in vivo Ephys: Rodent study with EEG or other in vivo recording systems (e.g., Plexon, NeuroNexus, Inscopix in vivo Ca++ imaging, or miniscope), and familiar with data analysis (e.g., MATLAB or python);

2) Molecular and cellular biology: molecular cloning, CRISPR editing, plasmid construction, virus packing, exon-intron splicing, epigenetics, neuron or microglia culture, RNA-sequencing, proteomics, or other multi-omics studies;

3) Patch-clamp electrophysiology: brain slice patch-clamp, Patch-seq (Patch-clamp assisted RNA-Sequencing) of cultured neurons or brain slices.

To apply, please send a current C.V. and a statement of research interests toDr. Yang Yang (yangyang@purdue.edu).Review of applications will continue until the positions are filled.

Purdue University is a top 10 public University in the US, and the College of Pharmacy ranks No. 7 nationally. Purdue University is in West Lafayette, Indiana, a beautiful and safe college town with affordable and comfortable living. It is located within short driving distances of two major cities (a two-hour driving distance from Chicago and one hour away from Indianapolis).

More information about Yang labresearch can be found via the following webpage (https://www.yangyanglab.org/)


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