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Postdoctoral Fellow - Gamma Herpesvirus Structural Biology Research and Vaccine Development

City of Hope

Job Description


About City of Hope

City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses.City of Hope research has been the basis for numerous breakthrough cancer medicines ,as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core,City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope's growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilitiesin Atlanta, Chicago and Phoenix.City of Hope's affiliated group of organizations includes Translational Genomics Research Institute and AccessHope TM .For more information about City of Hope, follow us on Facebook , Twitter , YouTube , Instagram and LinkedIn .

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities.Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding.We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary and Key Responsibilities

We are currently seeking highly motivated and talented individuals to fillfour postdoctoral positionsin the laboratory of Dr. Javier Gordon Ogembo at City of Hope'sDepartment of Immuno-Oncology. The positions are available in the following areas (check requirements for each area at the bottom) :

1. Gamma-herpesvirus vaccine development

2. Gamma-herpesvirus T cell immunology and therapeutics

3. Gamma-herpesvirus protein and antibody structural studies

4. Use of preclinical animal models to assess gamma-herpesvirus entry mechanism and vaccine development.

If you are looking for a challenging and exciting opportunity to advance your research career in cancer, we invite you to join our multi-disciplinary lab. Our lab is part of the Beckman Research Institute of City of Hope, a world-renowned National Comprehensive Cancer Center located just 20 miles from Los Angeles. City of Hope provides access to state-of-the-art facilities and resources excellent for transitional science, as well as a vibrant and collaborative research community. The Beckman Research Institute of City of Hope has several facilities that are approved by the FDA for the production of investigational drugs and biologics for use in clinical trials. These facilities are designed to meet rigorous regulatory standards and ensure the safety and efficacy of products developed at City of Hope. As a postdoctoral fellow in our lab, you will have the opportunity to access these facilities and work alongside leading experts in the field, contributing to cutting-edge research projects aimed at advancing our understanding the mechanisms of viral entry, oncovirology, vaccinology, and studying the interactions between viruses and host cells. In addition to the opportunity to work on exciting research projects, City of Hope offers excellent benefits, and a supportive work environment that encourages career development and advancement.

Basic education, experience and skills required for consideration:

Ideal candidates should have a Ph.D., Ph.D/DVM, or MD/Ph.Ddegree(s) in a related field and a strong background in one or more of the following areas: virology, protein/antibody biochemistry and structure, cancer vaccines, T-cell immunology, and the use of animal models in preclinical studies. Experience and proficiency in the following techniques are required for each position:

Gamma-herpesvirus vaccine development:

∑Cell culture and aseptic technique: culture, handling, and maintenance of bacterial and mammalian cells (multiple cell lines), cryopreservation.

∑Immuno-assays: western blot, ELISA, flow cytometry, immunofluorescence assay, immuno-histochemistry.

∑Virology assays: virus production and titration, virus neutralization, plaque assays.

∑DNA/RNA assays: DNA/RNA isolation from cells, viruses, and tissue, conventional PCR, qPCR, RT-qPCR, single cell RNA analysis ( not excluding ).

∑Experience with developing, handling and characterizing mRNA/DNA, virus-like particles, viral vector, nanoparticles vaccine candidatesand lipid nanoparticles formulation is a plus.

∑Pre-clinical animal models: animal handling (mice and/or rats), immunization/challenge, bodily fluid/blood collection, tissue processing.

Gamma-herpesvirus T cell immunology and therapeutics:

∑Cell culture and aseptic technique: culture, handling, and maintenance of bacterial and mammalian cells (multiple cell lines), cryopreservation.

∑Immune cell assays: immune cell isolation (animal tissue, PBMCs), ex vivo T cell stimulation and proliferation assays, cell viability and metabolic activity assays, ELISPOT, cell migration assays, phagocytosis assays, multi-color flow cytometry immune panel analysis, and cytotoxicity assays.

∑Virology assays: virus production and titration, virus neutralization, plaque assays ( not excluding ).

∑Immuno-assays: western blot, ELISA, flow cytometry, immunofluorescence assay, immuno-histochemistry.

∑DNA/RNA assays: DNA/RNA isolation from cells, viruses, and tissue, conventional PCR, qPCR, RT-qPCR, single cell RNA analysis.

∑Pre-clinical animal models: animal handling (mice and/or rats), immunization/challenge, bodily fluid/blood collection, tissue processing.

Gamma-herpesvirus protein and antibody structural studies

∑Cell culture and aseptic technique: culture, handling, and maintenance of bacterial and mammalian cells (multiple cell lines), cryopreservation.

∑Protein assays: protein production and purification, crystal structure, cryo-electron microscopy, nuclear magnetic resonance, circular dichroism (CD) spectroscopy, mass spectrometry, surface plasmon resonance.

∑Immuno-assays: western blot, ELISA, flow cytometry, immunofluorescence assay, immuno-histochemistry ( not excluding ).

∑DNA/RNA assays: DNA/RNA isolation from cells, viruses, and tissue, conventional PCR, qPCR, RT-qPCR, single cell RNA analysis ( not excluding ).

Use of preclinical animal models to assess gamma-herpesvirus entry mechanism and vaccine development.

∑Cell culture and aseptic technique: culture, handling, and maintenance of bacterial and mammalian cells (multiple cell lines), cryopreservation.

∑Virology assays: virus production and titration, virus neutralization, plaque assays.

∑Immuno-assays: western blot, ELISA, flow cytometry, immunofluorescence assay, immuno-histochemistry.

∑DNA/RNA assays: DNA isolation from cells, viruses, and tissue, conventional PCR, qPCR, RT-qPCR, single cell RNA analysis.

∑Pre-clinical animal models: animal handling (mice and/or rats), immunization, blood collection, tissue processing. Previous experience working with samples from non-human primates is an advantage.

In addition, candidates should have excellent communication and interpersonal skills, Strong attention to detail and excellent organizational skills, a track record of scientific productivity manifested in at least 2-3 first author publications in peer-reviewed journals, and the ability to work independently and as part of a dynamic team. Previous experience working in a GLP/cGMP- compliant laboratory settings will be an added advantage.

Additional Information:

∑For more information about Dr. Javier Gordon Ogembo's lab, please visit here.

∑The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc.This pay scale is subject to change from time to time.

∑As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


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