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Open Postdoctoral position, faculty mentor Kacper Rogala

Job Description

Postdoctoral positions are available in the Rogala Lab at Stanford University — .
Rogala Lab is a part of Stanford’s Department of Structural Biology , the Department of Chemical & Systems Biology . We are based in the Biomedical Innovations Building on the main Stanford campus, and our lab plays an integral role in the Stanford Cancer Institute , where we lead the development of structure-based approaches to novel cancer therapeutics.
We have open positions for dynamic post-doctoral candidates who exhibit exceptional dedication and a strong drive to discover fundamental mechanisms of proteins. Projects in the lab focus on proteins involved in nutrient sensing and nutrient trafficking — integral membrane transporters and large signaling complexes that assemble on biological membranes.
We are specifically looking for two types of candidates:

  • Structural biologists — Embark on the most challenging structural projects, pushing the boundaries of what can be accomplished with cryo-EM and other structural and biophysical techniques.
  • Protein biochemists / Cell biologists —  Bring your own unique expertise to our lab and lead us into uncharted territories. We will train you in our structural and chemical biology approaches, enhancing your skill set and equipping you with tools to tackle challenging biological problems at many different scales.

In general, if you are a highly motivated individual who thrives on cracking difficult biological mechanisms and wants to use that knowledge to advance our shared mission of combating cancer, then this is the perfect lab environment for you. You will find like-minded colleagues here — we are hungry for discovery and we want to make a positive impact on patients’s lives. We set the compensation of our postdocs to the Stanford rates, and we strongly encourage the candidates to explore applying for extramural fellowships and grants to support their research endeavors.
Joining a young lab like ours offers distinct advantages. You will have the opportunity to take ownership of near-complete projects, driving them to completion and publication as the first author. Simultaneously, we provide resources, support, and mentorship to initiate new projects from scratch, fostering your scientific growth. Our lab is friendly to postdocs from all walks of life, and we cherish trust, inclusiveness and intellectual curiosity. Your success is integral to our collective success, and we foster a growth mindset among all our trainees. Training and skills development are paramount, spanning a wide array of experimental and computational techniques. Through collaboration, a strong work ethic, soliciting feedback, and embracing new strategies, we cultivate an environment of innovation and facilitate novel discoveries within our team.
We are a team of structural and chemical biologists fascinated by how cells control their metabolism in response to nutrients. How are nutrients recognized by their protein sensors? How is their transport across cellular and intracellular membranes regulated? And, how is nutrient sensing integrated with other chemical signals, such as growth factors, to determine cellular decisions, especially the decision: to grow or not to grow? We are aiming to answer these fundamental questions at the level of ångstroms, nanometers, and micrometers — with cryo-EM, X-ray crystallography, and a full range of other techniques that span biology, chemistry, physics, and computation. Many proteins in nutrient signaling pathways are deregulated in cancer, and in parallel to the mechanistic structural work, we are also developing targeted chemical probes to modulate activity of these proteins in cells and organisms.
Our latest papers on this topic are:

  • Valenstein and Rogala et al. (2022) Structure of the nutrient-sensing hub GATOR2. Nature, 607(7919):610-616. PMID: 35831510 // Paywall-free article .
  • Rogala et al. (2019) Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366(6464):468-475. PMID: 31601708 [open-access] .
  • Shen and Rogala et al. (2019) Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex. Cell, 179(6):1319-1329.e8. PMID: 31704029 [open-access] .

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