The Human Genetics department at Genentech is looking for an exceptional computational scientist to study questions of key importance to the application of human genetics in drug discovery. Critical questions that we are now well-positioned to answer include: 

• What is the relationship between the genetic and mechanistic basis of disease risk vs disease progression, and is it the same across diseases? 

• Under what circumstances can we use polygenic (or polyproteomic) scores to stratify patients to support more efficient clinical trial recruitment, and how might such approaches be implemented in the context of ancestral diversity? 

While this position is primarily computational, the project is highly collaborative, with regular interactions across the organization. The successful applicant will have the opportunity to work closely with computational colleagues to access and analyze both internal data (from our trials) and from external data sets (FinnGen, UKBiobank and other biobanks) to address these questions. They will also have the opportunity for wider interactions, for example with colleagues in clinical development at Genentech, and with researchers in academia and in other companies who have interests in some of these questions (for example through our precompetitive involvement in FinnGen, ICDA and Open Targets).  Scientific insights resulting from this research are expected to be presented at external scientific conferences and published in high impact journals. This is an excellent postdoctoral opportunity for someone who is keen to contribute to our understanding of how human genetics (and genomics) can provide the evidence that drives the precision medicine of the future. 

Requirements:

• Ph.D. in Computational Biology, Bioinformatics, Human Genetics or related field

• Strong expertise in common disease genetics (GWAS, polygenic scores) and statistical genetics

• Proven experience with applying standard pipelines for the analysis of large-scale genetic data sets

• Demonstrated proficiency with R or Python

• Demonstrated ability to effectively communicate about complex genetic and statistical questions to both technical and non-technical audiences 

• Independent, highly motivated, and highly collaborative with the ability to work together with multi-disciplinary teams of computational and laboratory biologists 

• Enthusiastic about working in a scientific environment, especially one that is related to drug discovery and development 

• Quick learner, are curious about new areas and the opportunity to build expertise, and courageously and creatively take initiative to see your ideas implemented 

• Able to perform at a high level in a fast changing and demanding environment

For information about the McCarthy Lab at Genentech, please go to:

https://www.gene.com/scientists/our-scientists/mark-mccarthy

For information about the Postdoctoral Program at Genentech, please go to: 

https://www.gene.com/careers/university-and-early-career/postdocs

The expected salary range for this position based on the primary location of California is $64,800 and $120,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are available for this job posting.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.