The Department of Pathology and Cell Biology at Columbia University Irvine Medica Center seeks a highly qualified cancer biologist to support the study of the biology of breast cancer health disparities. These NIH-funded research programs implement an integrated focus on multiple different tissue-based biomarkers using digital and computational pathology to analyze 4 independent breast cancer cohorts complete with clinicopathological information. The focus will be on the use of digital pathology to characterize patient tissue samples using quantitative biomarker profiling, genomics, and morphology-based analysis of intrinsic tumor biological features in the tumor immune microenvironment utilizing quantitative immunohistochemistry-based proteomics, multiplex-immunofluorescence, deep-learning and artificial intelligence profiling of breast cancer morphological tissue features, single-cell based spatial gene expression analysis using in situ RNA hybridization, protein-complex profiling utilizing proximity ligation assays, RNA-seq based gene expression,  whole exome sequencing-based mutational profiling, and epigenetic profilings of the patient tissue samples. 

At CUIMC, we stand together because diverse experiences, perspective, and values enrich every dimension of our work. Join our team and see how your unique skills and experiences can create a real impact by changing lives.

Lab Mission:

The position will emphasize investigating the biology underlying the differences in disease occurrence and outcome in breast cancer and how it is influenced by race, ethnicity, and genetic ancestry. 

Job Function:

• Experience in biostatistics and/or bioinformatics or other methods/approaches in computational biology of biomarking profiling and survival curve analysis, basic interpretation of clinicopathological data
• Strong desire to work on fundamental translational research questions in cancer biology, including gene regulation, chromatin biology, and their influence on the tumor microenvironment. 
• A background in immunology is desirable but not required. 
• History of an ability to independently drive a project forward in a team-based interactive environment
• Willingness to provide mentorship to junior lab members are highly desirable.  
• Cell based assays in mammalian cells( proliferations, growth, death, apoptosis, senesence
• Recombinant DNA technology
• Mammalian tissue culture
• Western blotting
• Immunoprecipitation assays
• Cellular transformation assays.
• Immunohistochemistry