The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology lab that combines molecular biology, computational biology, structural biology and chemistry with various ‘Omics’ techniques such as proteomics to study the pathways and protein complexes involved in the regulation of protein abundance via the ubiquitin proteasome system that are often associated with human diseases, including cancer. The Fischer lab integrates structural biology, molecular biology and computational guided approaches to address fundamental questions about the mechanistic principles that govern signaling through the ubiquitin proteasome system.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The Fischer Lab (https://fischerlab.org/) seeks a highly motivated individual to join the team as a postdoctoral research fellow who will work on computational biology projects taking advantage of large amounts of experimental omics data to address fundamental questions in our understanding of the ubiquitin system. While we consider various backgrounds, a background in bioinformatics, computational biology and an interest in understanding how molecular machines work and the desire to tackle a major problem of great significance are absolutely essential.

Our laboratory is based at Dana-Farber Cancer Institute in Longwood Center and is an affiliate of the BCMP department at Harvard Medical School. We are affiliated with state of the art facilities for structural biology (cryo-EM, X-ray crystallography, NMR), chemistry, biophysics, cellular imaging, etc. and the lab also has expertise and equipment for mass spectrometry including Orbitrap Lumos tribrid mass spectrometers. Join our highly interactive team of scientists, postdocs, graduate students and technicians to work on understand signaling through the ubiquitin proteasome pathway and leverage these insights to test new avenues for therapeutic development.

• Recent Ph.D. or MD-PhD in bioinformatics, computational biology, biostatistics, computer science or related scientific fields.
• Ability to understand and analyze experimental data, prepare research publications and communicate results
• Working knowledge in analyzing large data sets
• Must demonstrate outstanding personal initiative and the ability to work effectively as part of an interdisciplinary team to discuss and present results, share ideas accurately, both in writing and verbally.
• Demonstrated ability to learn quickly

Expertise in following areas preferred:

• Computational Skills: Knowledge of UNIX/Linux. Strong programming skills in Python and statistics using R.
• Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. Experience with machine learning is desired.
• Strong interpersonal skills – ability to effectively interact with all levels of staff and external contacts
• Excellent analytical, organizational and time management skills.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.