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Postdoctoral Research Associate

Job Description


Requisition Details
GENERAL REQUISITION INFORMATION


EEO Statement:
UNMC is an Affirmative Action Equal Employment Opportunity Employer, including an equal opportunity employer of protected veterans and individuals with disabilities.
Location Omaha, NE
Requisition Number: 2023-097
Department Pharmacology/Exp Neuroscience 50000523
Business Unit(College/Institute) College of Medicine
FTE:
100
Reg-Temp Full-Time Regular
Work Schedule TBD by research needs
Requisition Category Research - Academic
Requisition Title Postdoctoral Research Associate
Job Title/Academic Rank Postdoctoral Research Associate
Additional Requisition Title
Appointment Type A1 - REG OTHER ACAD SAL
Salary Range Salary Commensurate with Experience
Job/EEO Category Professional Non-Faculty (Includes Other Academic)
Job Requisition Begin Date 03/17/2023

Position Qualification


Position Summary
Immediate opening for a highly motivated postdoctoral research associate to join a developing molecular biology group for delivery of CRISPR Therapeutics towards HIV elimination. The research seeks to merge revolutionary CRISPR-Cas9 technology with state-of-the-art nanoformulation technologies for targeted excision of integrated proviral DNA. Knowledge in recombinant DNA technologies, gene delivery, and mRNA CRISPR/Cas9 is required. Experience in HIV-1 biology and disease pathogenesis is helpful but not mandatory. To accelerate established efforts, team requires the candidate to partner with on-site scientists with virological, animal model and theranostic expertise. The program was the first the eliminate HIV-1 from a live animal and seeks to extend prior successes with improved gene recognition, delivery and exclusion of off-target toxicities. The overarching goal is HIV cure with a focus on CRISPR based gene editing of virus, viral receptors and required transcriptional factors.
Required Qualifications
Ph.D. in Molecular or cell biology, immunology or related field.
Knowledge in recombinant DNA technologies, gene delivery, and mRNA CRISPR/Cas9 is required.
Experiences in basic and applied molecular biology and prior mRNA or CRISPR-Cas9 research knowledge required for system characterization.
Supplemental Qualifications
Experience in HIV-1 biology and disease pathogenesis is helpful but not mandatory.
PCR, qPCR, western blot, cloning, cell culture.
Strong knowledge mRNA based gene editing.
Research experience with mice would be desirable
The candidate should have basic understanding of CRISPR Cas9 based gene editing (knock out knock in). Prior expertise in lentiviral/CRISPR vector design is preferred. Providing oversight and troubleshooting in basic and applied molecular biology is required that include, but not limited to, DNA/RNA extraction, restriction digestion, PCR, RT-qPCR, virus production, viral titration, transformation, transfection and transduction. The ability to work independently and cooperatively is essential. Candidates must have good writing and communication skills. Ample opportunities for career development, grant writing and faculty appointments possible.

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