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Pathogenesis of Emerging Respiratory Viruses
National Institute of Allergy and Infectious Diseases, Rocky Mountain Labs, Hamilton, MT
A postdoctoral IRTA position on the pathogenesis of emerging respiratory viruses is available in the Molecular Pathogenesis Unit within the Laboratory of Virology at the RML campus of NIAID in Hamilton, Montana. The laboratory studies high- and maximum-containment RNA viruses that cause severe lower respiratory tract disease, including coronaviruses, Nipah virus, and influenza A virus.
The Molecular Pathogenesis Unit is interested in the pathogenesis of emerging respiratory viruses on every level from host to molecule. The laboratory uses an experimental approach to increase our understanding of the disease induced by emerging respiratory viruses in the upper and lower respiratory tract, as well as in the central nervous system. Fundamental experimental approaches of the laboratory include molecular and cell-based techniques, including in human organoid cultures and a variety of animal models. Studies are carried out in biosafety level (BSL)-2, BSL-3, and BSL-4 laboratories. The Molecular Pathogenesis Unit considers diversity and inclusion the centerpiece of the teamís culture.
Successful applicants will be part of a diverse and multidisciplinary team focused on experimental approaches to relevant questions in the pathogenesis of emerging respiratory viruses. The project will specifically focus on the role of the upper respiratory tract as a barrier to infection of the lower respiratory tract and as a facilitator of transmission. The project will rely on the establishment of human organoid cultures and animal models suitable for studying high- and maximum-containment viruses.
An overview of the Molecular Pathogenesis Unitís most recent research with regards to pathogenesis of emerging respiratory viruses:
- Williamson et al. Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2. Nature 585: 273-276
- Speranza et al. Single-cell sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys. Sci Transl Med 13: eabe8146
- Speranza et al. Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques. LSA 5: e202101314
Highly motivated candidates who have a strong background in virology, molecular biology, computational biology, and immunology are encouraged to apply. Experience working in high-containment virology and experience working with organoids and animal models would be considered an advantage.
Well-developed oral and written communication skills are essential. Candidates must hold a Ph.D. in virology, molecular biology, or another appropriate discipline and have less than three years of postdoctoral experience. Applicants may be U.S. citizens, permanent residents, or international citizens (for an IRTA, visa requirements apply). Trainees will receive health insurance as well as a stipend commensurate with experience starting at $64,000 per year.
Applicants should send their curriculum vitae (CV), a letter expressing career goals and interests, and three letters of reference with contact information no later than April 15, 2023, to Kay Menk, Laboratory Operations Specialist, Laboratory of Virology, Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, 406-375-9624 (phone), 406-375-9620 (fax), or email†email@example.com.
RML is an NIAID campus with excellent flow cytometry, genomic, cryo-electron microscopy (EM) and high-resolution transmission electron microscopy (TEM), and veterinary core support that enables scientists to completely focus on their research. Located in the scenic Bitterroot valley of western Montana, RML is surrounded by some of the best hiking, skiing, kayaking, mountain biking, and trout fishing in North America.
Visit NIAID Careers for more information about working in NIAIDís dynamic atmosphere.
HHS, NIH, and NIAID are equal opportunity employers dedicated to equity, diversity, and inclusion.
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