Position Summary

In the Brossier lab, we are interested in identifying which factors (genetic, neurodevelopmental, environmental) increase the rate of tumorigenesis following oncogenic mutation and the molecular basis underlying this effect, with an eye towards using this information for patient risk assessment and to identify new targets for therapeutic intervention. We utilize animal models of Neurofibromatosis Type 1 (NF1)-related optic pathway glioma to accomplish these goals. We are additionally interested in how environmental exposures affect the non-tumor manifestations of NF1, particularly in regards to cognition. Projects in the lab revolve around three major themes: (1) how neurodevelopmental factors (cell type, age) affect response to oncogenic mutation, (2) how environmental factors modulate the effects of mutation on the cell of origin and tumor penetrance, and (3) how environmental factors affect neurodevelopment in relevant to cognition in NF1.

An ideal candidate for this position will have a Ph.D. or M.D./Ph.D. in biological sciences or related fields, as well as experience in molecular biology techniques. Programming skills are desired but not required. Experience with stem cell culture and/or mouse handling and procedures are highly desired. Applicants must have good spoken and written communication skills. Trainees will gain experience in mouse models, neural stem cell biology, neurodevelopment and translational research.

Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/ .

Primary Duties & Responsibilities

Trains under the supervision of a faculty mentor including (but not limited to):

• Manages their own project, which should lead to a first author publication.
• Develops proficiency in their chosen scientific discipline/field.
• Develops proficiency with technical skills, including (but not limited to) mouse genetic models, analysis of neural stem cell properties and molecular biology techniques.
• Develops proficiency in their ancillary skills, e.g., writing, public speaking, networking, critical evaluation of scientific documents, etc.
• Presents scientific work both inside and outside the University.
• Assists with grant preparation and reporting.
• Prepares and submits papers on research.
• Contributes to the design of research experiments.
• Evaluates research findings and assists in the reporting of the results.
• Conscientious discharge of his/her research responsibilities.
• Maintain conformity with ethical standards in research.
• Maintain compliance with good laboratory practice including the maintenance of adequate research records.
• Engage in open and timely discussion with his/her mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
• Collegial conduct towards co-trainees, staff members and members of the research group.
• Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Required Qualifications

Ph.D., M.D. or equivalent terminal or doctoral degree.

Preferred Qualifications

Demonstrated ability to implement laboratory procedures, conduct research and records findings.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

External Applicant Instructions

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Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu  or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO/AA Statement
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.