We have an opening for a highly passionate postdoctoral fellow with a strong background in RNA biochemistry, analytical chemistry, and/or functional analysis. The fellow will join the Genentech Research and Early Development (gRED) organization, with a primary appointment in the Small Molecule Analytical Chemistry (SMAC) Department, with a secondary appointment in the Molecular Biology Department. Research endeavors will involve the development of unique cell and biochemical assays, including sequencing approaches, to study the functional effects of chemical modifications within synthetic RNAs. The successful candidate will have the access to innovative therapeutic RNA molecules and technologies such as ONT GridIon and MinIon, Illumina miniSeq and NextSeq 2000, multi-dimensional liquid chromatography coupled to mass spectrometry (mD-LC-MS), and the opportunity to work in a highly collaborative and fruitful environment. The projects will involve working closely with groups across different functional expertise within Genentech and external collaborators.     

Who you are:

• Candidates must have a PhD in RNA analytical, functional or biological assessment, or a related field, with one or more first-author publications in high quality journals.

• Successful experience with the sequencing and structure determination of large RNA and their modifications (including Nanopore or nuclease-based techniques).

• Experience with biophysical characterization methods for protein-nucleic acid interactions and genome editing performance (such as the CRISPR/Cas9 technology) or in vitro assay development are beneficial.

• Practical knowledge of computational data analysis tools is desired.

• Pragmatic and focused researcher, driven to solve complex scientific problems independently and in a collaborative environment.

• Efficient oral and written communication skills are required.

More Information about the Genentech Postdoctoral Program:
http://www.gene.com/careers/academic-programs/postdocs

Relevant publications:

J. D. Alfonzo, J. A. Brown, P. H. Byers, V. G. Cheung, R. J. Maraia & R. L. Ross, A call for direct sequencing of full-length RNAs to identify all modifications, Nat. Gen. 53, 2021, 1113-1116.

A. Goyon, B. Scott, K. Kurita, C. M. Crittenden, D. Shaw, A. Lin, P. Yehl, and K. Zhang, Full Sequencing of CRISPR/Cas9 Single Guide RNA (sgRNA) via Parallel Ribonuclease Digestions and Hydrophilic Interaction Liquid Chromatography–High-Resolution Mass Spectrometry Analysis, Anal. Chem. 93, 2021, 44, 14792–14801

W. Stephenson, R. Razaghi, S. Busan, K. M. Weeks, W. Timp, and P. Smibert, Direct detection of RNA modifications and structure using single-molecule nanopore sequencing, Cell Genom. 2, 2022, 2, 100097

Relocation benefits are available for this position

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The expected salary range for this position based on the primary location of California is $64,000 and $120,300.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.