Postdoctoral Fellowship in Genome Engineering

Department of Hematology

The Tsai Laboratory is seeking dynamic and creative candidates for a fully supported postdoctoral fellowship on genome editing technologies for therapeutic treatment of genetic disorders.

CRISPR genome editors, adapted from bacterial adaptive immune systems, are transforming both basic biological research and genomic medicine. At St. Jude, we are working toward advancing these technologies towards patient treatments for sickle cell disease and bone marrow failure disorders.

You will have the opportunity to lead new projects in this exciting space such as:

• Developing and advancing genomic methods to define and measure gene editing “off-target” effects of precise base and prime editors for use in clinical applications.
• High-throughput protein engineering of precise CRISPR base and prime editors towards correction of patient-specific mutations.
• Developing novel strategies for editing of hematopoietic stem cells of genetic mutations that cause sickle cell disease and other hematological disorders

In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.

Please direct inquiries to: Shengdar Tsai, Ph.D.

Associate Member

Department of Hematology

St. Jude Children’s Research Hospital

shengdar .tsai@stjude.org

About St. Jude

St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for pediatric cancer and childhood disease. St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and was one of The Scientist’s top 10 “Best Places to Work in Academia” for seven consecutive years. St. Jude offers highly competitive stipends and benefits and actively fosters professional development. For more information, visit www.stjude.org.

Department of Hematology

Minimum Experience

Successful applicants will have a strong publication record, excellent writing skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, or a related area. To succeed in this position, you will have a strong molecular and cell biology background, with an emphasis on molecular cloning and genetic manipulation of mammalian cells. If you have additional experience with genome editing, hematopoietic stem cells, next-generation sequencing, protein purification, or automated liquid handling you are strongly encouraged to apply.