A position is available for a postdoctoral fellow with expertise in protein biochemistry, protein crystallography and/or cryoEM to join the Departments of Structural Biology and Molecular Oncology at Genentech, Inc. We have cutting edge facilities in-house for structural biology (X-ray, NMR & Cryo-EM), protein expression (E. coli , insect & mammalian) for intracellular, extracellular and membrane proteins, with weekly access to synchrotrons and internal access to cryo-EM instruments.

Responsibilities:

Active areas of research include the structure and function of protein complexes involved in the Wnt signaling pathway, important in colorectal cancer. The successful candidate will be involved in all aspects of structural biology including construct design, expression and purification of proteins, crystallization or cryoEM sample preparation, data collection, structure determination and analysis of protein structures. In addition, the candidate will characterize proteins using various biochemical & biophysical methods and collaborate with colleagues in Molecular Oncology to discover molecular mechanisms of signaling in colorectal cancer that are currently poorly understood.

Who You Are:

Team player with fearless attitude to tackle long standing, difficult problems in biological signaling using structural biology. Highly motivated and capable of independent work in a collaborative environment. Skillful in handling difficult proteins, strong background in protein production, crystallography and/or CryoEM demonstrated by successful purification, characterization and structure determination of challenging proteins as evidenced by a first author paper published or accepted in a peer-reviewed journal. Familiarity or expertise with enzymology, multiple biophysical methods is a plus.

Candidates must have a Ph.D. in structural biology, biophysics, biochemistry or a related discipline.

Relevant publications:

Structural basis for SHOC2 modulation of RAS signaling

Liau NPD, Johnson M, Izadi S, Gerosa L, Hammel M, Bruning JM, Wendorff TJ, Phung W, Hymowitz SG*, Sudhamsu J* Nature, 2022, 609, (400-407)

Dimerization Induced by C-Terminal 14–3–3 Binding Is Sufficient for BRAF Kinase Activation

Liau NPD, Venkatanarayan A, Quinn JG, Phung W, Malek S, Hymowitz SG, Sudhamsu J*

Biochemistry, 2020, 59, 41 (3982-3992)

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3 induced dimerization

Liau NPD, Wendorff TJ, Quinn JG, Steffek M, Phung W, Liu P, Tang J, Irudayanathan FJ, Izadi S, Shaw AS, Malek S, Hymowitz SG*, Sudhamsu J*

Nat. Struct. Mol. Biol., 2020, 27 (134-141)

For information about Sudhamsu's Lab at Genentech, please go to:

https://www.gene.com/scientists/our-scientists/jawahar-sudhamsu

For information about De Sauvage Lab at Genentech, please go to:

https://www.gene.com/scientists/our-scientists/frederic-de-sauvage

For information about the Postdoctoral Program at Genentech, please go to: 

https://www.gene.com/careers/university-and-early-career/postdocs

The expected salary range for this position based on the primary location of California is $64,800 and $120,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are available for this job posting.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.