The Longwood Center and Core for Structural & Chemical Biology at the Dana-Farber Cancer Institute, directed by Sirano Dhe-Paganon, in collaboration with multi-disciplinary research teams studies in vitro cancer models of multiple myeloma, meduloblastoma, and pancreatic & colon cancer. We are seeking research technicians to join our efforts to uncover novel molecular mechanisms and discover and develop drugs for these disease targets. General activities include designing & executing experiments on recombinantly-purified oncogenes such as KRAS, C-MYC, and β-Catenin and analyzing & interpreting results to advance drug candidates. Primary responsibilities include performing recombinant protein expression and purification and conduct invitro biophysical and biochemical assays and screens that test and validate screening hits, chemical probes, and lead compounds.

Responsibilities also include crystallizing & freezing proteins and determining high-resolution structures by x-ray diffraction or cryo-em in order to characterize and discover mechanism of action. Technicians attend departmental seminars, work closely with other scientists in the lab, collaborate extensively with colleagues at Dana Farber, are included as author on relevant publications and intellectual property documents, and often pursue graduate school, medical school, or biotech industry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• BA/MS degree required in biochemistry, biology, chemical biology, or equivalent preferred
• Exceptional communication skills, and ability to effectively present data within the laboratory and to collaborators
• Adept at working within cross-functional scientific teams to deliver project data within timelines
• At least two years of availability required

Please include a brief summary of research experience and names and contact information for three references.

Anticipated start date: May 2023

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.