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Postdoctoral Scholar - Physiology and Biophysics - Boron Lab

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Case Western Reserve University

Job Description


Position Objective

The responsibilities of this position include the conception, design, execution, and data analysis of experiments that focus on quantifying the transmembrane flux of carbon dioxide (CO2 ), oxygen (O2 ), and nitrogen (N2 ) through the plasma membrane.  The studies will focus in particular on CO2 and O2 flux through aquaporins, Rhesus proteins, and other candidate gas-channel proteins expressed in red blood cell (RBC) membranes. These studies are performed on RBCs isolated from various mammalian species including mice, cows and humans. The successful candidate will perform stopped-flow experiments to determine RBC O2 or CO2 permeability, Image Stream flow cytometry to determine RBC size and shape, and perform measurements of the affinity of hemoglobin for O2 . The successful candidate will also routinely make erythrocyte ghosts and work with the CWRU Mass Spectrometry cores to perform proteomic and lipidomic analyses. This position will work with animals. Finally, it is expected that the successful candidate will be familiar with the most up-to-date literature in the field, write papers, contribute to grant proposals, and assist in the design and optimization of any new experiments.

The applicant must have a PhD, MD/PhD, or equivalent degree in Physiology, Pharmacology, Biology, Biochemistry, Biophysics, or a related subject, and have a record of productivity evidenced by scholarly publications. Interested individuals should send a cover letter, CV, and contact information of three people who could provide recommendation letters of reference by email to boronlabsearch@case.edu

As a Postdoctoral Scholar, the candidate is expected to:

  • Document and analyze experimental results and present results in laboratory meetings, departmental seminars and scientific conferences.
  • Prepare manuscripts and contribute preliminary data and drafts of materials for grant proposals.
  • Work closely with other lab members to ensure projects are being completed according to the research plan and in organizing laboratory space and supplies.
  • Work with PI to submit and manage compliance with policies, procedures and regulations of the Animal Resource Center, IACUC, lab safety policy, and other applicable regulatory guidelines for which essential training will be provided.

    • Train and oversee rotation students and other research staff in the lab.

    PhD in biomedical sciences with hands-on experience in physiology experiments and animal work.

    PhD in physiology, biochemistry, pharmacology or related discipline with 0-5 years of postdoctoral experience.
    We will provide appropriate training in experimental approaches unfamiliar to the successful candidate.

    NIH salary scale.

  • Previous experience working with animals is preferred.
  • Prior experience with stopped flow, flow-cytometry or mass spectrometry preferred.
  • Ability to maintain research focus on a technically challenging project.
  • Strong organization skills and maintain a laboratory notebook, attention to scientific detail.
  • Experience with handling and working on animal model experiments.
  • Ability to work independently after essential training has been provided.
  • Effective oral and written communication skills.
  • Flexibility in work schedule to complete necessary study within deadlines.

    • Qualified candidates should send their CV, cover letter, and three professional references to Dr. Walter Boron via the email address boronlabsearch@case.edu


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