Position Summary

The Janowski Lab discovers and characterizes novel viruses, with a current focus on astrovirus VA1 (VA1). Astroviruses have been long assumed to be pathogens restricted to the gastrointestinal tract, but multiple human patients have been identified to have invasive astrovirus infection of the central nervous system.

We have successfully cultured VA1, the most commonly identified astrovirus species from cases of human encephalitis and developed the first cell culture model that supports replication of VA1 in central nervous system cells. In parallel, we have also developed a murine in vivo model of infection, and surprisingly, VA1 causes myocarditis in mice, suggesting this virus could have additional tissue tropisms beyond the gastrointestinal tract and central nervous system. We are now characterizing the pathogenesis of infection through our cell culture and mouse models of infection. These approaches will allow for important insights into the biology of an emerging family of viruses that cause invasive diseases in humans.

In addition, we are interested in characterizing conserved viral elements between viral families. VA1 contains a highly conserved RNA sequence known as the stem-loop II-like motif (s2m) that is also present in SARS coronaviruses including SARS CoV-2. Currently, the function of this motif is completely unknown despite its presence in multiple viral families. We have developed a reverse genetics system for VA1 and are using it to dissect the function of this motif.

We are seeking an energetic, highly motivated postdoctoral research associate to carry out in vitro and in vivo experiments. Techniques include RNA extraction, PCR, cloning and molecular biology, biochemistry, cell/tissue culture, fluorescence and confocal microscopy, and analysis of RNAseq or other data sets.

Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/ .

Required Qualifications

Ph.D., M.D., or an equivalent terminal doctoral degree.

Preferred Qualifications

• Experience with common molecular biology techniques, cell culture, virology, PCR, cloning, microscopy, mouse models of infection, and flow cytometry.
• Experience in immunology, virology, and molecular biology.
• Strong research skills.
• Effective oral and written communication skills.
• Highly motivated and creative with the ability to work both independently and within a team.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

To apply, please email a cover letter including a description of career goals, curriculum vitae, recent publication(s), and the names and contact information for three references (including the Ph.D. mentor, if applicable) to Dr. Andrew Janowski at abjanowski@wustl.edu .

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu  or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO/AA Statement
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.