Job Summary:

Vascular calcification is one of the major complications and cause of death in patients with chronic kidney disease (CKD). Currently, CKD affects an estimated 37 million people in the U.S. (15% of the adult population; more than 1 in 7 adults), There is no efficiency therapy available for the treatment of calcification. The major goal of this position is to find a novel therapeutic target for vascular calcification. This position is responsible for characterizing genetically modified mice and cell lines to elucidate the molecular mechanism of vascular calcification. The person will remove genes in the entire genome of cells using RNAi or CRISPR (clustered regularly interspaced short palindromic repeats) gene editing to examine which gene participates in the pathogenesis of vascular calcification. The results will be reported in high-impact journals.

Key Responsibilities

• Performing confocal microscopes
• Characterizing genetically engineered cell lines
• Performing CRISPR gene editing
• Performing general biochemical molecular biological techniques such as quantitative polymerase chain reaction (PCR) and immunoblot analysis
• Writing papers
• Helping supervisor to write grants.

Why Join Us:

For more than 10 years, the Miyazaki laboratory has strived to find the underlying mechanisms of chronic kidney disease (CKD) complications such as vascular calcification and therapeutic targets for treating these diseases.

Our overall goal is to identify novel therapeutic targets for treatment of CKD complications. In pursuit of this goal, we have investigated molecules and mechanisms that trigger ectopic mineralization and vascular toxicities in CKD. In the past, we have discovered that several metabolites (i.e., saturated fatty acids and bile acids) and kidney-specific proteins (i.e., TMEMs) as well as intracellular signaling (i.e., autophagy, ER stress and cell death) contribute to CKD complications. Our group currently focuses on the following three NIH funded projects: 1) the role of novel cell death pathways in the regulation of vascular calcification, 2) identification of novel metabolites contributing to CKD complications and 3) identification of novel kidney-specific proteins contributing to CKD complications.

For more details on the Miyazaki lab, please visit the following link:

https://medschool.cuanschutz.edu/renal/research-new/miyazaki-lab

The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off – vacation, sick, and holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness .

Diversity and Equity:

The University of Colorado Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.

• Graduation from an accredited college or university with a PhD or MD.
• Requires experience with animal studies
• Requires experience with cell cultures

 Preferred Qualifications: 

The post-doctoral fellow would ideally have excellent knowledge of techniques of physiology, cell biology or advanced microscopies in addition to excellent publication record.

Knowledge, Skills and Abilities:

To be successful in this position, candidate will need at least the following: 

Enthusiasm and to be hard working.

How to Apply:

For full consideration, please submit the following document(s):

Questions should be directed to: Betsy Pike, Renal Division Human Resources, betsy.pike@cuanschutz.edu

Applications are accepted electronically ONLY at www.cu.edu/cu-careers .

Screening of Applications Begins:

Immediately, and continues until position is filled. 

Anticipated Pay Range:

The starting salary range (or hiring range ) for this position has been established as HIRING RANGE:

Post-Doctoral Fellows are paid according to the NIH Stipend Levels, which are currently: 

Career Level                            Stipend Amount

         0                                            $54,840

         1                                            $55,224

         2                                            $55,632

         3                                            $57,852

         4                                            $59,784

         5                                            $61,992

         6                                            $64,296

         7                                            $66,600

The above salary range (or hiring range ) represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu ?.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

The University of Colorado has a requirement for COVID-19 vaccinations and full completion thereof by 9/1/21 or upon start date.  Information regarding this requirement, and exemptions can be found at:

Anschutz: https://www.ucdenver.edu/docs/librariesprovider284/default-document-library/3000-general-admission/3012---covid-19-vaccination-requirement-and-compliance.pdf?sfvrsn=4e9df3ba_2

Unit-Specific Exemptions:

• Anschutz Campus – Accommodations may be granted for medical or religious reasons.

The University of Colorado seeks individuals with demonstrated commitment to creating an inclusive learning and working environment. We value the ability to engage effectively with students, faculty and staff of diverse backgrounds.